Lipid Based Formulations of Biopharmaceutics Classification System (BCS) Class II Drugs: Strategy, Formulations, Methods and Saturation
| Autor: | T. de Vringer, D. Toropilová, I. Šoltýsová |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Veterinary medicine
lipid formulations 02 engineering and technology Computational biology Pharmacology 021001 nanoscience & nanotechnology Biopharmaceutics Classification System 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine spontaneous emulsification biopharmaceutics classification system – class ii drugs SF600-1100 maximum saturation 0210 nano-technology Saturation (chemistry) Mathematics |
| Zdroj: | Folia Veterinaria, Vol 60, Iss 4, Pp 63-69 (2016) |
| ISSN: | 2453-7837 |
| DOI: | 10.1515/fv-2016-0040 |
| Popis: | Active ingredients in pharmaceuticals differ by their physico-chemical properties and their bioavailability therefore varies. The most frequently used and most convenient way of administration of medicines is oral, however many drugs are little soluble in water. Thus they are not sufficiently effective and suitable for such administration. For this reason a system of lipid based formulations (LBF) was developed. Series of formulations were prepared and tested in water and biorelevant media. On the basis of selection criteria, there were selected formulations with the best emulsification potential, good dispersion in the environment and physical stability. Samples of structurally different drugs included in the Class II of the Biopharmaceutics classification system (BCS) were obtained, namely Griseofulvin, Glibenclamide, Carbamazepine, Haloperidol, Itraconazol, Triclosan, Praziquantel and Rifaximin, for testing of maximal saturation in formulations prepared from commercially available excipients. Methods were developed for preparation of formulations, observation of emulsification and its description, determination of maximum solubility of drug samples in the respective formulation and subsequent analysis. Saturation of formulations with drugs showed that formulations 80 % XA and 20 % Xh, 35 % XF and 65 % Xh were best able to dissolve the drugs which supports the hypothesis that it is desirable to identify limited series of formulations which could be generally applied for this purpose. |
| Databáze: | OpenAIRE |
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