Synthesis and Studies of Alkynyl Pyrimidinones as Metaphase Inhibitors

Autor:	Tore Benneche, Gunnar Keilen, Jan Solberg, Reidar Oftebro, Kjell Undheim, Lars I. Elding
Rok vydání:	1991
Předmět:	Alkylation General Chemical Engineering Ether Alcohol Pyrimidinones Combinatorial chemistry chemistry.chemical_compound Deprotonation Liver chemistry In vivo Propargyl Humans Metaphase Cells Cultured
Zdroj:	Acta Chemica Scandinavica. 45:731-735
ISSN:	0904-213X
Popis:	Methods are described for the syntheses of chloromethyl propargyl ethers and propargyl halides substituted with a hydroxyalkyl group, and their use in alkylation reactions of 2-pyrimidinones. The N-alkynyl derivatives are reversible inhibitors of mitosis in the metaphase of the cell-cycle. The in vivo screening was on Chang liver cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0236adabdf57256caa5ee339891c31 https://doi.org/10.3891/acta.chem.scand.45-0731 Zobrazit plný text záznamu