The emergence of Lyme disease
| Autor: | Jenifer Coburn, Lisa J. Glickstein, Allen C. Steere |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Lyme Disease
medicine.medical_specialty North central Public health Review Series General Medicine Disease Biology bacterial infections and mycoses medicine.disease Immune clearance biology.organism_classification Virology Ticks Lyme disease Immune system Immunology medicine Animals Humans Macrophage Borrelia burgdorferi |
| Zdroj: | Journal of Clinical Investigation. 113:1093-1101 |
| ISSN: | 0021-9738 |
| Popis: | Since its identification nearly 30 years ago, Lyme disease has continued to spread, and there have been increasing numbers of cases in the northeastern and north central US. The Lyme disease agent, Borrelia burgdorferi, causes infection by migration through tissues, adhesion to host cells, and evasion of immune clearance. Both innate and adaptive immune responses, especially macrophage- and antibody-mediated killing, are required for optimal control of the infection and spirochetal eradication. Ecological conditions favorable to the disease, and the challenge of prevention, predict that Lyme disease will be a continuing public health concern. |
| Databáze: | OpenAIRE |
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