Effects of Chinese herbal medicine Fuzhisan on autologous neural stem cells in the brain of SAMP-8 mice
| Autor: | Shi-Rong Wen, De-Sheng Wang, Tie-Gang Wang, Feng-Xin Hu, Guo-Wei Zhang, Hui Yang, Xu-Ling Li |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Gerontology
Aging Cell Survival Subventricular zone Hippocampus Mice Inbred Strains Pharmacology Hippocampal formation Biochemistry law.invention Mice Lateral ventricles Endocrinology Neural Stem Cells Alzheimer Disease law Genetics medicine Animals Maze Learning Molecular Biology Nootropic Agents Cell Proliferation business.industry Neurogenesis Cell Biology medicine.disease Immunohistochemistry Neural stem cell medicine.anatomical_structure Alzheimer's disease business Phytotherapy Drugs Chinese Herbal |
| Zdroj: | Experimental Gerontology. |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/j.exger.2010.12.004 |
| Popis: | Fuzhisan (FZS), a Chinese herbal complex prescription, has been used in the treatment of Alzheimer's disease (AD) for more than 16 years. However the underlying mechanism remains to be explored. The effects of the aqueous extract of FZS on the cognitive functions of the aged mice and the pharmacological basis for its therapeutic efficacy were investigated. The results showed that FZS improved impaired cognitive ability of aged SAMP-8 mice. FZS (2.4, 4.8 g/kg/d) increased hippocampal neurogenesis and the long-term survival of BrdU-labeled cells without affecting the proportion of BrdU-positive neurons and glial cells. FZS also increased the number of BrdU-positive cells in the subventricular zone (SVZ) of the lateral ventricles of 8-month-old SAMP-8 mice. These studies suggest that FZS upregulates neurogenesis by increasing proliferation of neural progenitor cells and prolonging survival of the newborn cells in the hippocampal DG. FZS may be beneficial for the treatment of senile dementia, especially Alzheimer's disease. |
| Databáze: | OpenAIRE |
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