Augmentation of Autoantibodies by Helicobacter pylori in Parkinson’s Disease Patients May Be Linked to Greater Severity

Autor: Shen-Yang Lim, Arif Anwar, Ai Huey Tan, Ranganath Gudimella, Hidayah Isa, Gunasekaran Suwarnalata, Mun Fai Loke, Jamuna Vadivelu, Sanjiv Mahadeva
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Parkinson's disease
Physiology
lcsh:Medicine
Gene Expression
Disease
Pathology and Laboratory Medicine
Biochemistry
Levodopa
0302 clinical medicine
Endocrinology
Helicobacter
Immune Physiology
Medicine and Health Sciences
Medicine
lcsh:Science
education.field_of_study
Multidisciplinary
PDGFB
Immune System Proteins
Movement Disorders
biology
Drugs
Neurodegenerative Diseases
Parkinson Disease
Neurochemistry
Proto-Oncogene Proteins c-sis
Middle Aged
Bacterial Pathogens
Neurology
NFIA
Medical Microbiology
Female
Pathogens
Neurochemicals
Research Article
Population
Immunology
Microbiology
Antibodies
Helicobacter Infections
03 medical and health sciences
Growth Factors
DNA-binding proteins
Genetics
Humans
Gene Regulation
education
Microbial Pathogens
Autoantibodies
Aged
Pharmacology
Bacteria
Endocrine Physiology
Helicobacter pylori
business.industry
lcsh:R
Autoantibody
Organisms
Biology and Life Sciences
Proteins
biology.organism_classification
medicine.disease
Regulatory Proteins
NFI Transcription Factors
030104 developmental biology
Eukaryotic Initiation Factor-4A
Etiology
lcsh:Q
business
030217 neurology & neurosurgery
Biomarkers
Transcription Factors
Neuroscience
Zdroj: PLoS ONE
PLoS ONE, Vol 11, Iss 4, p e0153725 (2016)
ISSN: 1932-6203
Popis: Parkinson's disease (PD) is the second most common chronic and progressive neurodegenerative disorder. Its etiology remains elusive and at present only symptomatic treatments exists. Helicobacter pylori chronically colonizes the gastric mucosa of more than half of the global human population. Interestingly, H. pylori positivity has been found to be associated with greater of PD motor severity. In order to investigate the underlying cause of this association, the Sengenics Immunome protein array, which enables simultaneous screening for autoantibodies against 1636 human proteins, was used to screen the serum of 30 H. pylori-seropositive PD patients (case) and 30 age- and gender-matched H. pylori-seronegative PD patients (control) in this study. In total, 13 significant autoantibodies were identified and ranked, with 8 up-regulated and 5 down-regulated in the case group. Among autoantibodies found to be elevated in H. pylori-seropositive PD were included antibodies that recognize Nuclear factor I subtype A (NFIA), Platelet-derived growth factor B (PDGFB) and Eukaryotic translation initiation factor 4A3 (eIFA3). The presence of elevated autoantibodies against proteins essential for normal neurological functions suggest that immunomodulatory properties of H. pylori may explain the association between H. pylori positivity and greater PD motor severity.
Databáze: OpenAIRE
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