Chikungunya virus outbreak in Sint Maarten: Long-term arthralgia after a 15-month period
| Autor: | L E de Langen, Eva Pilot, J H T C van den Kerkhof, Marieta Braks, M Henry, L J T Bouwman, R Pijnacker, C M M Peters, Ewout Fanoy, Johan Reimerink, V Asin Oostburg |
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| Přispěvatelé: | RS: CAPHRI - R4 - Health Inequities and Societal Participation, Metamedica |
| Rok vydání: | 2018 |
| Předmět: |
Male
Pediatrics chikungunya Disease medicine.disease_cause 0302 clinical medicine INFECTION 030212 general & internal medicine Chikungunya Child MUSCULOSKELETAL PAIN Aged 80 and over biology virus diseases General Medicine Middle Aged Arthralgia TRAVELERS Infectious Diseases Child Preschool Female Chikungunya virus Adult medicine.medical_specialty Adolescent DISORDERS 030231 tropical medicine Virus lcsh:Infectious and parasitic diseases Young Adult 03 medical and health sciences EPIDEMIC vector-borne diseases medicine Humans Caribbean Sint Maarten lcsh:RC109-216 Aged Retrospective Studies Aedes business.industry Outbreak Retrospective cohort study biology.organism_classification Chikungunya Fever Parasitology business Complication PERSISTENT ARTHRALGIA |
| Zdroj: | Journal of Vector Borne Diseases, 55(2), 137-143. Malaria Research Center Journal of Vector Borne Diseases, Vol 55, Iss 2, Pp 137-143 (2018) |
| ISSN: | 0972-9062 |
| DOI: | 10.4103/0972-9062.242561 |
| Popis: | Background & objectives: The first chikungunya (CHIK) epidemic in the Americas was reported in December 2013. Chikungunya virus (CHIKV) causes an acute febrile illness and is transmitted to humans by Aedes mosquitoes. Although earlier studies have described long-term clinical manifestations of CHIK patients infected with the East/Central/South African (ECSA) genotype, little is known about persistent manifestations in the Caribbean region, for which the Asian genotype is responsible. The objective of this study was to describe the presence of persisting clinical manifestations, specifically arthralgia, in CHIKV-infected patients on the Caribbean Island, Sint Maarten, 15 months after onset of the disease. Methods: This retrospective cohort study included confirmed CHIK patients that were recorded by the participating general practitioners (GPs) during the chikungunya outbreak in 2014 in Sint Maarten. Between March and July 2015, 15 months after the onset of disease, patients were interviewed via telephone about the presence, duration and impact of clinical CHIKV manifestations. Results: In total, 56 patients were interviewed (median age 47 yr), of which 30 (54%) were females. Out of the total interviewed patients, 52 (93%) reported arthralgia for the first three months after the disease onset, of which 23 (44%) patients reported to have persistent arthralgia, 15 months after the disease onset. Pain intensity of persistent arthralgia was perceived as mild in the majority of patients (n = 14; 60%), moderate in 7 (30%) patients and severe in 2 (9%) patients. During the acute phase of disease, most patients had to miss school or work (n = 39; 72%) due to clinical CHIKV manifestations and reported a negative impact on daily activities (n = 36; 57%). Interpretation & conclusion: Results suggested that persisting arthralgia is a frequent complication in CHIK patients included in the study. Future research on strain-specific clinical long-term manifestations and on their impact on daily life of patients, in the form of a comparative study between patients and controls, is recommended. |
| Databáze: | OpenAIRE |
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