Mono-2-ethylhexyl phthalate induced loss of mitochondrial membrane potential and activation of Caspase3 in HepG2 cells
| Autor: | Wei Xiong, Guangtao Yang, Jing Yuan, Jianshu Wang, Qizhi Qin, Kaimin Rao, Qian Wang, Ying Jiang, Xi Chen |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Cell Survival
Health Toxicology and Mutagenesis Caspase 3 Apoptosis Mitochondrion Toxicology Cell Line Andrology chemistry.chemical_compound Bcl-2-associated X protein Diethylhexyl Phthalate Humans Viability assay bcl-2-Associated X Protein Pharmacology chemistry.chemical_classification Membrane Potential Mitochondrial Reactive oxygen species biology General Medicine Glutathione Hep G2 Cells Caspase 9 Cell biology chemistry Proto-Oncogene Proteins c-bcl-2 Cell culture biology.protein |
| Zdroj: | Environmental toxicology and pharmacology. 33(3) |
| ISSN: | 1872-7077 |
| Popis: | L02 and HepG2 cells were exposed to mono-(2-ethylhexyl) phthalate (MEHP) at concentrations of 6.25-100μM. After 48h treatment, MEHP decreased HepG2 cell viability in a concentration-dependent manner and L02 cell viability in the 50 and 100μM groups (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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