Sesquiterpene lactones from Mikania micrantha and Mikania cordifolia and their cytotoxic and anti-inflammatory evaluation
| Autor: | María Isabel Chávez, María Teresa Ramírez-Apan, Yuridia Torres, V Eunice Ríos, Alejandra León, Rubén A. Toscano, Angel E. Bravo-Monzón, Guillermo Delgado, Francisco J. Espinosa-García |
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| Rok vydání: | 2014 |
| Předmět: |
Magnetic Resonance Spectroscopy
Cell Survival medicine.drug_class Stereochemistry Anti-Inflammatory Agents Moderate activity Crystallography X-Ray Sesquiterpene Anti-inflammatory Inhibitory Concentration 50 Lactones Mice Sesquiterpenes Guaiane chemistry.chemical_compound Cell Line Tumor Drug Discovery medicine Animals Edema Humans Cytotoxic T cell Mikania Mikania micrantha Pharmacology Molecular Structure biology Plant Extracts Chemistry General Medicine Plant Components Aerial biology.organism_classification Disease Models Animal Mikania cordifolia Sesquiterpenes Human cancer |
| Zdroj: | Fitoterapia. 94:155-163 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2014.02.006 |
| Popis: | The guaianolide 8-epi-mikanokryptin (1) and the melampolide 11Hβ-11,13-dihydromicrantholide (2) along with known sesquiterpene lactones (3-13) and other constituents were isolated from the aerial parts of different populations of Mikania micrantha and Mikania cordifolia collected in several states of Mexico. The relative and absolute configurations of 1 were determined by X-ray diffraction and CD analysis, respectively. Considering the (1)H and (13)C NMR chemical shift similarities and the H-H coupling constant values, a [(1)D(14), (15)D5] conformation was established for micrantholides (2, 8-13). We tested nearly all the sesquiterpene lactones for antiproliferative activity in human cancer cell lines, and they exhibited moderate activity. Additionally, in a mouse ear model of edema induced by TPA, the anti-inflammatory activities were marginal. |
| Databáze: | OpenAIRE |
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