Fatal Enterovirus-related Myocarditis in a Patient with Devic's Syndrome Treated with Rituximab
| Autor: | Mouna Lazrek, Benjamin Longère, Hélène Zéphir, Basile Verdier, Francis Juthier, Sandrine Morell-Dubois, Céline Goéminne, Johana Béné, Anne-Laure Piton, Fanny Vuotto, Xristos Gkizas, Guillaume Gantois, Romain Dubois, Gilles Lemesle, D. Launay, Vincent Elsermans, Ava Diarra |
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| Rok vydání: | 2020 |
| Předmět: |
Myocarditis
medicine.drug_class viruses Context (language use) medicine.disease_cause Monoclonal antibody 03 medical and health sciences 0302 clinical medicine rituximab hemic and lymphatic diseases Medicine Diseases of the circulatory (Cardiovascular) system 030212 general & internal medicine Devic’s syndrome 030203 arthritis & rheumatology S syndrome Neuromyelitis optica business.industry enterovirus Clinical Syndromes medicine.disease RC666-701 Immunology Enterovirus Rituximab Differential diagnosis myocarditis Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiac Failure Review Cardiac Failure Review, Vol 7, Iss, Pp-(2021) |
| ISSN: | 2057-7540 |
| Popis: | Enteroviruses are a frequent source of infection and among the most common central nervous system viral pathogens. Enteroviruses – in particular, the Coxsackie B viruses – are a known cause of myocarditis. Rituximab is a genetically engineered chimeric anti-CD20 monoclonal antibody. Many reports in the literature suggest a higher risk of infection following repeated rituximab therapy, including viral infection. However, observations of enterovirus-related myocarditis in the context of rituximab treatment are scarce. The authors describe the case of a patient with neuromyelitis optica spectrum disorder who developed severe and fatal enterovirus-related myocarditis after rituximab therapy with a difficult differential diagnosis of autoimmune or giant-cell myocarditis. This case highlights the importance of complete diagnostic workup in difficult cases of myocarditis, including endomyocardial biopsies. |
| Databáze: | OpenAIRE |
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