Open Field Release of Genetically Engineered Sterile Male Aedes aegypti in Malaysia
| Autor: | Neil Naish, Sarah Scaife, A A Siti Rahidah, Wong Hong Ming, Pam Gray, A Nazni Wasi, Camilla Beech, Oreenaiza Nordin, Chandru Angamuthu, Selvi Subramaniam, Derric Nimmo, Shahnaz Murad, Norzahira Raduan, Suria Marlina Mansor, Renaud Lacroix, Lim Kwee Wee, Seshadri S. Vasan, Teoh Guat Ney, Geneviève Labbé, Rosemary Susan Lees, Luke Alphey, A T Norhaida Hanum, Sawaluddin Salman, Lee Han Lim, Andrew R. McKemey |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Mosquito Control Climate Dengue virus medicine.disease_cause Mosquitoes Dengue fever Animals Genetically Modified Dengue Aedes Biological Systems Engineering Multidisciplinary Genetically Modified Organisms Mosquito control Infectious Diseases Medicine Female Viral disease Genetic Engineering Research Article Biotechnology Science Bioengineering Aedes aegypti Biology Microbiology Statistics Nonparametric Vector Biology parasitic diseases medicine Animals Humans Infertility Male business.industry Genetically engineered fungi Malaysia Vectors and Hosts Dengue Virus biology.organism_classification medicine.disease Virology Insect Vectors Vector (epidemiology) business Animal Distribution Zoology Entomology Transgenics |
| Zdroj: | PLoS ONE PLoS ONE, Vol 7, Iss 8, p e42771 (2012) |
| ISSN: | 1932-6203 |
| Popis: | BackgroundDengue is the most important mosquito-borne viral disease. In the absence of specific drugs or vaccines, control focuses on suppressing the principal mosquito vector, Aedes aegypti, yet current methods have not proven adequate to control the disease. New methods are therefore urgently needed, for example genetics-based sterile-male-release methods. However, this requires that lab-reared, modified mosquitoes be able to survive and disperse adequately in the field.Methodology/principal findingsAdult male mosquitoes were released into an uninhabited forested area of Pahang, Malaysia. Their survival and dispersal was assessed by use of a network of traps. Two strains were used, an engineered 'genetically sterile' (OX513A) and a wild-type laboratory strain, to give both absolute and relative data about the performance of the modified mosquitoes. The two strains had similar maximum dispersal distances (220 m), but mean distance travelled of the OX513A strain was lower (52 vs. 100 m). Life expectancy was similar (2.0 vs. 2.2 days). Recapture rates were high for both strains, possibly because of the uninhabited nature of the site.Conclusions/significanceAfter extensive contained studies and regulatory scrutiny, a field release of engineered mosquitoes was safely and successfully conducted in Malaysia. The engineered strain showed similar field longevity to an unmodified counterpart, though in this setting dispersal was reduced relative to the unmodified strain. These data are encouraging for the future testing and implementation of genetic control strategies and will help guide future field use of this and other engineered strains. |
| Databáze: | OpenAIRE |
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