Age at menopause, reproductive history, and venous thromboembolism risk among postmenopausal women: the Women's Health Initiative Hormone Therapy clinical trials
| Autor: | Geneviève Plu-Bureau, Barbara B. Cochrane, Marianne Canonico, Marcia L. Stefanick, JoAnn E. Manson, Pierre-Yves Scarabin, Mary Jo O'Sullivan |
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| Přispěvatelé: | Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Paris Descartes - Paris 5 (UPD5), Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Maison du patrimoine Oral de Bourgogne (Anost) (MPOB), Stanford Prevention Research Center, Stanford Medicine, Stanford University-Stanford University, University of Washington [Seattle], Departments of Ophthalmology and Microbiology and Molecular Genetics, Harvard Medical School [Boston] (HMS), National Heart, Lung, and Blood Institute, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), SZTAJNBOK, Pascale, Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris Descartes - Paris 5 ( UPD5 ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Maison du patrimoine Oral de Bourgogne ( MPO ), Maison du patrimoine Oral de Bourgogne, Stanford University School of Medicine, Harvard Medical School [Boston] ( HMS ) |
| Rok vydání: | 2013 |
| Předmět: |
MESH : Venous Thromboembolism
MESH: Reproductive History MESH: Menopause medicine.medical_treatment MESH : Aged 030204 cardiovascular system & hematology MESH: Venous Thromboembolism MESH: Pregnancy 0302 clinical medicine MESH : Child MESH: Risk Factors Pregnancy Risk Factors MESH: Child MESH : Female 030212 general & internal medicine Child Reproductive History MESH: Aged Clinical Trials as Topic MESH : Estrogen Replacement Therapy MESH: Middle Aged Obstetrics Women's Health Initiative Hazard ratio Estrogen Replacement Therapy MESH : Menopause Age Factors MESH : Menarche Obstetrics and Gynecology [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie Venous Thromboembolism MESH : Adult Middle Aged MESH : Risk Factors 3. Good health MESH : Women's Health Menopause Postmenopause Parity MESH : Ovariectomy MESH: Menarche MESH : Postmenopause Menarche Female MESH: Postmenopause Adult medicine.medical_specialty MESH: Clinical Trials as Topic Adolescent Ovariectomy MESH: Ovariectomy Article 03 medical and health sciences MESH : Adolescent MESH : Reproductive History medicine Humans MESH : Middle Aged cardiovascular diseases MESH : Parity Aged MESH: Adolescent MESH: Age Factors Gynecology MESH: Humans Proportional hazards model business.industry MESH : Humans MESH: Parity Oophorectomy MESH: Adult equipment and supplies medicine.disease MESH: Estrogen Replacement Therapy MESH : Clinical Trials as Topic MESH : Pregnancy [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie Women's Health [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie MESH : Age Factors Hormone therapy business MESH: Women's Health MESH: Female |
| Zdroj: | Menopause (New York, N.Y.) Menopause (New York, N.Y.), 2014, 21 (3), pp.214-20. ⟨10.1097/GME.0b013e31829752e0⟩ Menopause (New York, N.Y.), 2014, 21 (3), pp.214-20. 〈10.1097/GME.0b013e31829752e0〉 |
| ISSN: | 1530-0374 |
| DOI: | 10.1097/GME.0b013e31829752e0⟩ |
| Popis: | International audience; This study aims to investigate venous thromboembolism (VTE) risk in relation to age at menopause, age at menarche, parity, bilateral oophorectomy, and time since menopause, as well as any interaction with randomized hormone therapy (HT) assignment, among postmenopausal women. Using pooled data from the Women's Health Initiative HT clinical trials including 27,035 postmenopausal women aged 50 to 79 years who had no history of VTE, we assessed the risk of VTE in relation to age at menopause, age at menarche, parity, bilateral oophorectomy, and time since menopause by Cox proportional hazards models. Linear trends, quadratic relationships, and interactions of reproductive life characteristics with HT on VTE risk were systematically tested. During follow-up, 426 women reported a first VTE, including 294 non-procedure-related events. No apparent interaction of reproductive life characteristics with HT assignment on VTE risk was detected, and there was not a significant association between VTE and age at menarche, age at menopause, parity, oophorectomy, or time since menopause. However, analyses restricted to non-procedure-related VTE showed a U-shaped relationship between age at menopause and thrombotic risk that persisted after multivariable analysis (P < 0.01). Compared with women aged 40 to 49 years at menopause, those who had early menopause (age 55 y) had a significantly increased VTE risk (hazard ratio [95% CI]: 1.8 [1.2-2.7] and 1.5 [1.0-2.4], respectively). Reproductive life characteristics have little association with VTE and do not seem to influence the effect of HT on thrombotic risk among postmenopausal women. Nevertheless, early and late onset of menopause might be newly identified risk factors for non-procedure-related VTE. |
| Databáze: | OpenAIRE |
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