Dihydroagarofuranoid Sesquiterpenes, a Lignan Derivative, a Benzenoid, and Antitubercular Constituents from the Stem of Microtropis japonica
| Autor: | Chien Fang Peng, Ih-Sheng Chen, Chang Ling Miaw, Chang Syun Yang, Jih Jung Chen |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Stereochemistry
Antitubercular Agents Taiwan Pharmaceutical Science Pharmacognosy Sesquiterpene Lignans Analytical Chemistry Celastraceae chemistry.chemical_compound Drug Discovery Benzene Derivatives Phenols Antibacterial agent Pharmacology Lignan Plants Medicinal Molecular Structure Plant Stems biology Organic Chemistry Mycobacterium tuberculosis biology.organism_classification Terpenoid Complementary and alternative medicine chemistry Molecular Medicine Sesquiterpenes Derivative (chemistry) |
| Zdroj: | Journal of Natural Products. 71:1016-1021 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np800097t |
| Popis: | Four new compounds, including two new dihydroagarofuranoid sesquiterpenes, 8-benzoyloxymutangin (1) and 15-acetoxyorbiculin G (2), a new lignan derivative, 9,9'- O-di-(Z)-feruloyl-(-)-secoisolariciresinol (3), and a new benzenoid, 5'-methoxyevofolin B (4), have been isolated from the stem of Microtropis japonica, together with 20 known compounds (5- 24). 3-Ethoxy-4-hydroxybenzaldehyde (5) was identified from a natural source for the first time. The structures of these new compounds were determined through analyses of physical data. 15-Acetoxyorbiculin G (2), celahin C (6), and salasol A (7) exhibit antituberculosis activities (MICs < or = 39.6 microM) against Mycobacterium tuberculosis H 37Rv in vitro. |
| Databáze: | OpenAIRE |
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