HLA Matching Trumps Donor Age: Donor-Recipient Pairing Characteristics That Impact Long-Term Success in Living Donor Kidney Transplantation in the Era of Paired Kidney Exchange
| Autor: | John Milner, Marc L. Melcher, Garet Hil, Phillip C. Fry, Matthew Ronin, Tom D'Alessandro, Patrick Shannon, Jeff Veale, Brian Lee |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Transplantation medicine.medical_specialty Kidney business.industry 030232 urology & nephrology Human leukocyte antigen 030230 surgery medicine.disease Living donor Kidney Transplantation Donor age Surgery 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Internal medicine Medicine Graft survival business Kidney transplantation |
| Zdroj: | Transplantation Direct |
| ISSN: | 2373-8731 |
| Popis: | Background We sought to identify donor characteristics influencing long-term graft survival, expressed by a novel measure, kidney life years (KLYs), in living donor kidney transplantation (LDKT). Methods Cox and multiple regression analyses were applied to data from the Scientific Registry for Transplant Research from 1987 to 2015. Dependent variable was KLYs. Results Living donor kidney transplantation (129 273) were performed from 1987 to 2013 in the United States. To allow sufficient time to assess long-term results, outcomes of LDKTs between 1987 and 2001 were analyzed. After excluding cases where a patient died with a functioning graft (8301) or those missing HLA data (9), 40 371 cases were analyzed. Of 18 independent variables, the focus became the 4 variables that were the most statistically and clinically significant in that they are potentially modifiable in donor selection (P |
| Databáze: | OpenAIRE |
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