Relation Between Lipid Profile and New-Onset Atrial Fibrillation in Patients With Systemic Hypertension (From the Swedish Primary Care Cardiovascular Database [SPCCD])
Autor: | Linus Schiöler, Karin Manhem, Georgios Mourtzinis, Louise Cedstrand Wallin, Kristina Bengtsson Boström, Per Hjerpe, Thomas Kahan, Jan Hasselström |
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Rok vydání: | 2018 |
Předmět: |
Male
medicine.medical_specialty Time Factors Population Blood Pressure 030204 cardiovascular system & hematology Lower risk 03 medical and health sciences symbols.namesake 0302 clinical medicine Sex Factors Risk Factors Internal medicine Atrial Fibrillation medicine Humans 030212 general & internal medicine Poisson regression Registries education Aged Dyslipidemias Retrospective Studies Sweden education.field_of_study medicine.diagnostic_test Primary Health Care business.industry Incidence Atrial fibrillation Middle Aged medicine.disease Prognosis Lipids Confidence interval New onset atrial fibrillation Hypertension symbols Cardiology Female Cardiology and Cardiovascular Medicine Lipid profile business Dyslipidemia Biomarkers Follow-Up Studies |
Zdroj: | The American journal of cardiology. 122(1) |
ISSN: | 1879-1913 |
Popis: | The relation between dyslipidemia and atrial fibrillation (AF) development is still controversial. To assess the impact of lipid profile on new-onset AF, we followed 51,020 primary-care hypertensive patients without AF at baseline. After a mean follow-up time of 3.5 years, AF occurred in 2,389 participants (4.7%). We evaluated the association between total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, and new-onset AF. In a Poisson regression model fully adjusted for common risk factors of AF, we found that 1.0 mmol/l (39 mg/dl) increase in total cholesterol was associated with 19% lower risk of new-onset AF (95% confidence interval [CI] 9% to 28%), and 1.0 mmol/l (39 mg/dl) increase in low-density lipoprotein cholesterol was associated with 16% lower risk of new-onset AF (95% CI 3% to 27%). Gender-specific Poisson regression analyses revealed that increase in total cholesterol by 1.0 mmol/l (39 mg/dl) was found to be associated with lower risk of new-onset AF with 21% in men (95% CI 8% to 32%), and 18% in women (95% CI 1% to 31%). There was no association between high-density lipoprotein cholesterol or triglycerides and new-onset AF, neither in the whole population with respect to separate gender. In conclusion, in a large hypertensive population we found an inverse association between total cholesterol and new-onset AF for both men and women. Our results confirm previous reports of a dyslipidemia paradox, and extend these observations to the hypertensive population. |
Databáze: | OpenAIRE |
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