Multikinase inhibitor-induced liver injury in patients with cancer: A review for clinicians
Autor: | Cosmin Sebastian Voican, Marie Danielou, Olivier Mir, Bernard Fromenty, Camille Houron, Gabriel Perlemuter |
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Přispěvatelé: | Inflammation, microbiome, immunosurveillance (MI2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Université Paris-Saclay, AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Gustave Roussy (IGR), Centre Hospitalier Universitaire [Rennes], Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Cytokines, chimiokines et immunopathologie, Université Paris-Sud - Paris 11 (UP11)-IFR13-Institut National de la Santé et de la Recherche Médicale (INSERM), This research did not receive any specific grant from funding agencies in the public, commercial, or not-for profit sectors., Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Drug-induced liver injury [SDV]Life Sciences [q-bio] [SDV.CAN]Life Sciences [q-bio]/Cancer Asymptomatic Multikinase inhibitor 03 medical and health sciences 0302 clinical medicine Neoplasms Internal medicine Humans Medicine Adverse effect Grading (tumors) Liver injury Hepatitis business.industry Hepatotoxicity [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology Hematology medicine.disease 3. Good health Clinical trial 030104 developmental biology Chemical and Drug Induced Liver Injury Chronic 030220 oncology & carcinogenesis Liver function Chemical and Drug Induced Liver Injury medicine.symptom business |
Zdroj: | Critical Reviews in Oncology/Hematology Critical Reviews in Oncology/Hematology, Elsevier, 2021, 157, pp.103127. ⟨10.1016/j.critrevonc.2020.103127⟩ Critical Reviews in Oncology/Hematology, 2021, 157, pp.103127. ⟨10.1016/j.critrevonc.2020.103127⟩ |
ISSN: | 1040-8428 |
Popis: | International audience; BACKGROUND: Multikinase inhibitors (MKI) are targeted molecular agents that have revolutionized cancer management. However, there is a paucity of data concerning MKI-related liver injury risk and clinical guidelines for the management of liver toxicity in patients receiving MKI for cancer are scarce. DESIGN: We conducted a PubMed search of articles in English published from January 2000 to December 2018 related to hepatotoxicity of the 29 FDA-approved MKIs at doses used in clinical practice. The search terms were the international non-proprietary name of each agent cross-referenced with «hepatotoxicity», «hepatitis», «hepatic adverse event», or «liver failure», and «phase II clinical trial», «phase III clinical trial», or «case report». RESULTS: Following this search, 140 relevant studies and 99 case reports were considered. Although asymptomatic elevation of aminotransferase levels has been frequently observed in MKI clinical trials, clinically significant hepatotoxicity is a rare event. In most cases, the interval between treatment initiation and the onset of liver injury is between one week and two months. Liver toxicity is often hepatocellular and less frequently mixed. Life-threatening MKI-induced hepatic injury has been described, involving fulminant liver failure or death. Starting from existing data, a description of MKI-related liver events, grading of hepatotoxicity risk, and recommendations for management are also given for various MKI molecules. CONCLUSION: All MKIs can potentially cause liver injury, which is sometimes irreversible. As there is still no strategy available to prevent MKI-related hepatotoxicity, early detection remains crucial. The surveillance of liver function during treatment may help in the early detection of hepatotoxicity. Furthermore, the exclusion of potential causes of hepatic injury is essential to avoid unnecessary MKI withdrawal. |
Databáze: | OpenAIRE |
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