Applying adverse outcome pathways and species sensitivity-weighted distribution to predicted-no-effect concentration derivation and quantitative ecological risk assessment for bisphenol A and 4-nonylphenol in aquatic environments: A case study on Tianjin City, China
| Autor: | Lijun Wang, Guangshui Na, Juying Wang, Ying Wang, Xindong Ma, Jinsong Zhao, Jingli Mu, Xianhai Yang, Zhifeng Zhang, Zhongsheng Lin, Humin Zong |
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| Rok vydání: | 2017 |
| Předmět: |
endocrine system
Aquatic Organisms China 010504 meteorology & atmospheric sciences Endpoint Determination Health Toxicology and Mutagenesis 010501 environmental sciences 01 natural sciences Risk Assessment chemistry.chemical_compound Phenols Species Specificity Adverse Outcome Pathway Toxicity Tests Environmental Chemistry Animals Ecological risk Predicted no-effect concentration Benzhydryl Compounds 0105 earth and related environmental sciences Adverse Outcome Pathways Ecology Geography Aquatic ecosystem Hazard Hazard quotient Nonylphenol chemistry Environmental chemistry Environmental science Weighted distribution Water Pollutants Chemical Environmental Monitoring |
| Zdroj: | Environmental toxicology and chemistry. 37(2) |
| ISSN: | 1552-8618 |
| Popis: | Adverse outcome pathways (AOPs) are a novel concept that effectively considers the toxic modes of action and guides the ecological risk assessment of chemicals. To better use toxicity data including biochemical or molecular responses and mechanistic data, we further developed a species sensitivity-weighted distribution (SSWD) method for bisphenol A and 4-nonylphenol. Their aquatic predicted-no-effect concentrations (PNECs) were derived using the log-normal statistical extrapolation method. We calculated aquatic PNECs of bisphenol A and 4-nonylphenol with values of 4.01 and 0.721 µg/L, respectively. The ecological risk of each chemical in different aquatic environments near Tianjin, China, a coastal municipality along the Bohai Sea, was characterized by hazard quotient and probabilistic risk quotient assessment techniques. Hazard quotients of 7.02 and 5.99 at 2 municipal sewage sites using all of the endpoints were observed for 4-nonylphenol, which indicated high ecological risks posed by 4-nonylphenol to aquatic organisms, especially endocrine-disrupting effects. Moreover, a high ecological risk of 4-nonylphenol was indicated based on the probabilistic risk quotient method. The present results show that combining the SSWD method and the AOP concept could better protect aquatic organisms from adverse effects such as endocrine disruption and could decrease uncertainty in ecological risk assessment. Environ Toxicol Chem 2018;37:551-562. © 2017 SETAC. |
| Databáze: | OpenAIRE |
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