Autoantibody testing in idiopathic inflammatory myopathies
| Autor: | Baziel G.M. van Engelen, Johan Lim, Ger J. M. Pruijn, Olivier Benveniste, Marianne de Visser, Anneke J. van der Kooi, Anke Rietveld, Christiaan G J Saris |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Weakness neuroimmunology Polymyositis polymyositis 03 medical and health sciences 0302 clinical medicine Medicine Humans Aged Autoantibodies 030203 arthritis & rheumatology biology Myositis business.industry Clinical Laboratory Techniques Interstitial lung disease Autoantibody Bio-Molecular Chemistry General Medicine Middle Aged Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] medicine.disease Neuroimmunology Idiopathic inflammatory myopathies Immunology incl body myositis Idiopathic Inflammatory Myopathy biology.protein Female Neurology (clinical) neuromuscular medicine.symptom Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Practical Neurology, 19, 284-294 Practical Neurology, 19, 4, pp. 284-294 |
| ISSN: | 1474-7758 |
| Popis: | Contains fulltext : 207009.pdf (Publisher’s version ) (Closed access) The diagnosis and classification of idiopathic inflammatory myopathies are based mainly on clinical and histological features. The discovery of myositis-specific and myositis-associated antibodies has simplified the (sub)classification of inflammatory myopathies. Patients suspected of having an idiopathic inflammatory myopathy should undergo routine antibody testing to gain more insight into distinct phenotypes, comorbidities, treatment response and prognosis. Furthermore, autoantibody testing can help in patients with atypical patterns of weakness or with an unresolved limb-girdle myopathic phenotype, or interstitial lung disease. However, some important technical and methodological issues can hamper the interpretation of antibody testing; for example, some antibodies are not included in the widely available line blots. We aim to provide a practical review of the use of autoantibody testing in idiopathic inflammatory myopathies in clinical practice. |
| Databáze: | OpenAIRE |
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