Epithelial-mesenchymal transition, and collective and individual cell migration regulate epithelial changes in the amikacin-damaged organ of Corti
| Autor: | Jean-Luc Puel, Michel Eybalin, Marc Lenoir, Sabine Ladrech |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Histology Epithelial-Mesenchymal Transition Context (language use) Biology 03 medical and health sciences Cell Movement Cell Plasticity otorhinolaryngologic diseases medicine Animals Epithelial–mesenchymal transition Rats Wistar Cell adhesion Molecular Biology Amikacin Organ of Corti Cochlea Cell migration Epithelial Cells Cell Biology Cell biology Rats Medical Laboratory Technology 030104 developmental biology medicine.anatomical_structure Hair cell |
| Zdroj: | Histochemistry and cell biology. 148(2) |
| ISSN: | 1432-119X |
| Popis: | Characterizing the microenvironment of a damaged organ of Corti and identifying the basic mechanisms involved in subsequent epithelial reorganization are critical for improving the outcome of clinical therapies. In this context, we studied the expression of a variety of cell markers related to cell shape, cell adhesion and cell plasticity in the rat organ of Corti poisoned with amikacin. Our results indicate that, after severe outer hair cell losses, the cytoarchitectural reorganization of the organ of Corti implicates epithelial-mesenchymal transition mechanisms and involves both collective and individual cell migratory processes. The results also suggest that both root cells and infiltrated fibroblasts participate in the homeostasis of the damaged epithelium, and that the flat epithelium that may emerge offers biological opportunities for late regenerative therapies. |
| Databáze: | OpenAIRE |
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