Predictive and Prognostic Value of High-density Lipoprotein Cholesterol in Young Male Patients with Acute Myocardial Infarction
Autor: | Nan Li, Zhao Li, Ji Huang |
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Rok vydání: | 2017 |
Předmět: |
Male
Adult Acute coronary syndrome medicine.medical_specialty Adolescent Myocardial Infarction lcsh:Medicine 030204 cardiovascular system & hematology Risk Assessment Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Acute Myocardial Infarction medicine Humans cardiovascular diseases 030212 general & internal medicine Myocardial infarction Young adult Risk factor Proportional Hazards Models Cause of death High-density Lipoprotein Cholesterol Prognosis business.industry Proportional hazards model Cholesterol HDL lcsh:R Hazard ratio General Medicine medicine.disease Surgery Acute Disease Cardiology Original Article lipids (amino acids peptides and proteins) business Mace |
Zdroj: | Chinese Medical Journal, Vol 130, Iss 1, Pp 77-82 (2017) Chinese Medical Journal |
ISSN: | 0366-6999 |
Popis: | Background: The level of high-density lipoprotein cholesterol (HDL-C) is an important risk indicator and used in risk factor counting and quantitative risk assessment; however, the effect of HDL-C in young male patients with acute myocardial infarction (AMI) is unclear. The aim of this study was to investigate the effect of HDL-C in young male patients. Methods: We recruited 267 consecutive young male patients (≤44 years) diagnosed with AMI. Other 247 participants free from coronary heart disease were enrolled as controls. HDL-C levels of AMI patients and controls were evaluated to analyze the predictive value on AMI. According to the cutoff point of 1.04 mmol/L HDL-C, patients of AMI were divided into two subgroups (normal HDL-C group and low HDL-C group) and were followed up for 2 years. Clinical end points included all major adverse coronary events (MACEs): the main cause of death, nonfatal myocardial infarction, readmissions for acute coronary syndrome, arrhythmias, or revascularization. The prognostic value of HDL-C was evaluated using Cox regression according to MACE. Results: Patients of AMI had decreased proportion in normal HDL-C group compared to controls (47.2% vs. 57.9%; P = 0.017). Logistic regression analysis showed that there was an inverse relationship between HDL-C and AMI in young males. In the low HDL-C subgroup of AMI patients ( n = 141), 34 (24.1%) patients experienced a MACE during the 2-year follow-up, compared with 15 (11.9%) patients in normal HDL-C subgroup ( n = 126). The Cox regression analysis showed that HDL-C was an independent predictor of a MACE during the follow-up period (hazard ratio = 0.354, P = 0.006). Conclusion: HDL-C was an important parameter for predicting the risk and the clinical outcomes of AMI in young male patients. |
Databáze: | OpenAIRE |
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