Preferences for Fractures and Other Glucocorticoid-Associated Adverse Effects among Rheumatoid Arthritis Patients
| Autor: | Thomas N. Taylor, Walton Sumner, Kenneth G. Saag, Paul C. Utrie, Linda Merlino, Amy S. Mudano, Indranil Bagchi, Elizabeth A. Chrischilles |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychometrics Osteoporosis Population Time-trade-off Arthritis Rheumatoid Fractures Bone 03 medical and health sciences 0302 clinical medicine Rating scale Surveys and Questionnaires Internal medicine medicine Humans 030212 general & internal medicine Adverse effect education Glucocorticoids Aged Hip fracture education.field_of_study business.industry 030503 health policy & services Health Policy Chronic pain Middle Aged medicine.disease Logistic Models Patient Satisfaction Rheumatoid arthritis Quality of Life Female 0305 other medical science business |
| Zdroj: | Medical Decision Making. 21:122-132 |
| ISSN: | 1552-681X 0272-989X |
| Popis: | Objective. The objective of this study was to determine rheumatoid arthritis (RA) patients’ preferences for validated health state scenarios depicting glucocorticoid adverse events, predictors of these preferences, and psychometric properties of different preference techniques in this population. Methods. Preferences were elicited by rating scale and time trade-off methods. Time trade-offs included trading current health for either time spent alive in an adverse health state for chronic conditions (time trade-off) or time spent in a sleeplike state for acute conditions (sleep trade-off). Results. A total of 107 subjects with long-standing RA participated in the preference interviews. Mean preference values (rating scale/trade-off) were lowest for serious fracture adverse events, including hip fracture requiring a nursing home stay (0.55 ± 0.22/0.76 ± 0.36) and vertebral fracture with chronic pain (0.59 ± 0.23/0.67 ± 0.35), and highest for cataracts (0.84 ± 0.17/0.96 ± 0.09) and wrist fracture (0.82 ± 0.18/0.81 ± 0.29). Rating scales had a stronger correlation (r= 0.88) with physician ranking of scenarios than trade-off methods (r = 0.31). All methods were feasible and demonstrated good reliability, while rating scale method showed better construct validity than trade-off techniques. Conclusion. Relative to their current health, RA patients assigned low preference values to many glucocorticoid adverse events, particularly those associated with chronic fracture outcomes. Results varied with the preference measure used, indicating that methodological attributes of preference determinations must be considered in clinical decision making. |
| Databáze: | OpenAIRE |
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