Evaluation of constitutional chromosome aberrations in hematologic disorders
| Autor: | Carolina Bárbara Belli, Roxana Cerretini, Irma Slavutsky, Irene Larripa, Susana Acevedo, Christian Chena |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Cancer Research Down syndrome medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD Adolescent Population Inmunología Aneuploidy Chromosomal translocation Biology CHROMOSOME ABERRATIONS Internal medicine HEMATOLOGIC DISORDERS Genetics medicine Humans Risk factor Child education Molecular Biology Chromosome Aberrations education.field_of_study Incidence (epidemiology) Infant Newborn Cytogenetics Infant Middle Aged medicine.disease Hematologic Diseases CYTOGENETICS CONSTITUTIONAL ALTERATIONS Medicina Básica Child Preschool Cytogenetic Analysis Female Trisomy |
| Zdroj: | Cancer Genetics and Cytogenetics. 134:133-137 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/s0165-4608(01)00621-5 |
| Popis: | We have reviewed 4164 patients with various hematologic disorders cytogenetically studied in our laboratory during the last 25 years to analyze the frequency of constitutional chromosome aberrations (CCA) and to evaluate their association with hematologic malignancies. Our population of patients included 1133 pediatric patients and 3031 adults. Twenty-four (0.58%) cases showed CCA. They included four patients with Robertsonian translocations, one patient with a balanced translocation, two patients with sex chromosome abnormalities, and 17 cases with Down syndrome (DS). Nonsignificant differences among the frequency of patients with CCA from our hematologic series and those observed in the two largest combined surveys of livebirth published (0.65-0.84%) were found. The incidence of DS patients in our population (0.41%) was approximately three times higher than of that observed at birth (0.12-0.17%; P |
| Databáze: | OpenAIRE |
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