The clinical significance of indeterminate pulmonary nodules in melanoma patients at baseline and during follow-up chest CT
| Autor: | Laura Jimenez-Juan, Teresa M. Petrella, Nicole J. Look Hong, Hua Lu, Anastasia Oikonomou, Pascal N. Tyrrell, Frances C. Wright, Magdy Soliman, Petros Zezos |
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| Rok vydání: | 2019 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty lcsh:R895-920 Article Ground-glass opacity Metastasis 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Radiology Nuclear Medicine and imaging Clinical significance FU follow-up Stage (cooking) Melanoma X-ray computed tomography Multiple Pulmonary Nodules business.industry Nodule (medicine) medicine.disease GGO ground glass opacity 030220 oncology & carcinogenesis IPN indeterminate pulmonary nodules Radiology Multiple pulmonary nodules medicine.symptom Indeterminate business |
| Zdroj: | European Journal of Radiology Open European Journal of Radiology Open, Vol 6, Iss, Pp 85-90 (2019) |
| ISSN: | 2352-0477 |
| DOI: | 10.1016/j.ejro.2019.02.003 |
| Popis: | Objective: This study aims to determine an appropriate timeline to monitor indeterminate pulmonary nodules (IPN) in melanoma patients to confirm metastatic origin. Materials and Methods: 588 clinically non-metastatic melanoma patients underwent curative intent surgery during 3 years. Patients with baseline chest CT and at least one follow-up (FU) CT were retrospectively analyzed to assess for IPN. Patients with definitely benign nodules, metastases and non-melanoma malignancies were excluded. Change in volume from first to FU CT, initial diameter (D1) and volume (V1), distance from pleura, peripheral and perifissural location, density and clinical stage were evaluated. Nodules were volumetrically measured on CTs and were considered metastases if they increased in size between two CTs or if increase was accompanied by multiple new nodules or extrapulmonary metastases. Results: 148 patients were included. Two out of 243 baseline IPN detected in 70 patients, increased significantly in volume in 3 and 5 months and were proven metastases. During FU, 86% of 40 interval IPN detected in 28 patients, were proven metastases. Interval nodule (p |
| Databáze: | OpenAIRE |
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