Regulatory CD4+ CD25+ Foxp3+ T cells expand during experimental Plasmodium infection but do not prevent cerebral malaria
| Autor: | Ana Margarida Vigário, Antonio Bandeira, Adrien Six, Olivier Gorgette, Pierre-André Cazenave, Hélène C. Dujardin, Sylviane Pied, Tânia Cruz |
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| Přispěvatelé: | Instituto Gulbenkian de Ciência [Oeiras] (IGC), Fundação Calouste Gulbenkian, Universidade da Madeira (UMA), Immunophysiopathologie Infectieuse, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Développement des Lymphocytes, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Plasmodium berghei MESH: Spleen MESH: Interleukin-2 Receptor alpha Subunit Malaria Cerebral Spleen MESH: Malaria Cerebral 03 medical and health sciences Interleukin 21 Mice 0302 clinical medicine In vivo MESH: Forkhead Transcription Factors MESH: Mice Inbred C57BL parasitic diseases medicine Animals MESH: Plasmodium berghei MESH: Animals [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology IL-2 receptor MESH: Mice 030304 developmental biology 0303 health sciences biology Interleukin-2 Receptor alpha Subunit FOXP3 MESH: CD4-Positive T-Lymphocytes Forkhead Transcription Factors biology.organism_classification In vitro MESH: Male 3. Good health Mice Inbred C57BL Infectious Diseases medicine.anatomical_structure Immunology [SDV.IMM]Life Sciences [q-bio]/Immunology Parasitology CD8 030215 immunology |
| Zdroj: | International Journal for Parasitology International Journal for Parasitology, Elsevier, 2007, 37 (8-9), pp.963-73. ⟨10.1016/j.ijpara.2007.01.004⟩ International Journal for Parasitology, 2007, 37 (8-9), pp.963-73. ⟨10.1016/j.ijpara.2007.01.004⟩ |
| ISSN: | 0020-7519 |
| DOI: | 10.1016/j.ijpara.2007.01.004⟩ |
| Popis: | International audience; Pathogenic CD8+ T cells are implicated in the physiopathological mechanisms leading to experimental cerebral malaria (CM) in Plasmodium berghei ANKA (PbA) infected mice. Therefore, we hypothesised that in CM susceptible mice the neuropathology could be, at least in part, the result of an inefficient control of pathogenic effector T cells by CD4+ CD25+ Treg cells. Remarkably, the number of CD4+ CD25high T cells expressing Foxp3 increased in the spleen during the course of infection. These cells displayed an activated phenotype and consistent with that, CD4+ CD25high Treg cells isolated from PbA-infected mice showed an enhanced regulatory activity in vitro. Surprisingly, these cells do not migrate to the brain at the time of neurological symptoms as the conventional CD4+ T cells do. CM was not exacerbated in anti-CD25 treated mice when infected with PbA one month after treatment, even if splenic CD8+ T cells expressing CD69 increased in these mice. Taken together, these results show that P. berghei infection leads to an increase of the number of splenic CD4+ CD25high Treg cells exhibiting in vitro suppressive function, but they do not seem to be involved in vivo in the protection against CM. |
| Databáze: | OpenAIRE |
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