Serum S-100β as a possible marker of blood–brain barrier disruption

Autor:	Thomas J. Masaryk, Gene H. Barnett, Miranda Kapural, Damir Janigro, John Perl, Peter A. Rasmussen, Marc R. Mayberg, D Apollo, Lj Krizanac-Bengez
Rok vydání:	2002
Předmět:	medicine.medical_specialty Lymphoma Endothelium Enolase Central nervous system Ischemia S100 Calcium Binding Protein beta Subunit Biology Blood–brain barrier Drug Administration Schedule Central Nervous System Neoplasms Predictive Value of Tests Internal medicine medicine Humans Infusions Intra-Arterial Mannitol Nerve Growth Factors Molecular Biology Neuroinflammation General Neuroscience S100 Proteins Neurodegeneration medicine.disease Endocrinology medicine.anatomical_structure nervous system Blood-Brain Barrier Phosphopyruvate Hydratase Immunology Neurology (clinical) Biomarkers Developmental Biology Astrocyte
Zdroj:	Brain Research. 940:102-104
ISSN:	0006-8993
Popis:	Two brain-specific proteins, S-100beta and neuron-specific enolase (NSE), are released systemically after cerebral lesions, but S-100beta levels sometimes rise in the absence of neuronal damage. We hypothesized that S-100beta is a marker of blood-brain barrier (BBB) leakage rather than of neuronal damage. We measured both proteins in the plasma of patients undergoing iatrogenic BBB disruption with mannitol, followed by chemotherapy. Serum S-100beta increased significantly after mannitol infusion (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae59cfeea324594ae35c24181c0afd0 https://doi.org/10.1016/s0006-8993(02)02586-6 Zobrazit plný text záznamu Full Text from ScienceDirect