Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity
| Autor: | Anupam Goel, Pamlea N. Brady, Margaret A. Johnson |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Protein Conformation
Poly ADP ribose polymerase Inflammation Review Biology Microbiology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine PARP1 Stress granule Stress Physiological Transcriptional regulation medicine Animals Humans Author Correction Molecular Biology 030304 developmental biology chemistry.chemical_classification 0303 health sciences General Immunology and Microbiology Immunity Plants Cell biology Disease Models Animal Infectious Diseases Enzyme chemistry 030220 oncology & carcinogenesis Host-Pathogen Interactions Poly(ADP-ribose) Polymerases medicine.symptom Signal transduction |
| Zdroj: | Microbiology and Molecular Biology Reviews |
| ISSN: | 1098-5557 1092-2172 |
| DOI: | 10.1128/mmbr.00038-18 |
| Popis: | The literature review presented here details recent research involving members of the poly(ADP-ribose) polymerase (PARP) family of proteins. Among the 17 recognized members of the family, the human enzyme PARP1 is the most extensively studied, resulting in a number of known biological and metabolic roles. This review is focused on the roles played by PARP enzymes in host-pathogen interactions and in diseases with an associated inflammatory response. In mammalian cells, several PARPs have specific roles in the antiviral response; this is perhaps best illustrated by PARP13, also termed the zinc finger antiviral protein (ZAP). Plant stress responses and immunity are also regulated by poly(ADP-ribosyl)ation. PARPs promote inflammatory responses by stimulating proinflammatory signal transduction pathways that lead to the expression of cytokines and cell adhesion molecules. Hence, PARP inhibitors show promise in the treatment of inflammatory disorders and conditions with an inflammatory component, such as diabetes, arthritis, and stroke. These functions are correlated with the biophysical characteristics of PARP family enzymes. This work is important in providing a comprehensive understanding of the molecular basis of pathogenesis and host responses, as well as in the identification of inhibitors. This is important because the identification of inhibitors has been shown to be effective in arresting the progression of disease. |
| Databáze: | OpenAIRE |
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