Identification and molecular characterization of a S. agalactiae strain lacking the capsular locus
| Autor: | Giovanna Alfarone, Marco Pataracchia, Monica Imperi, Lucilla Baldassarri, Simona Recchia, Roberta Creti |
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| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Restriction Mapping Locus (genetics) Biology Group B Streptococcus agalactiae Microbiology Serology Medical microbiology Pregnancy RNA Ribosomal 16S Streptococcal Infections medicine Humans Pregnancy Complications Infectious Gene Bacterial Capsules DNA Primers Genetics Regulation of gene expression Polysaccharides Bacterial Sequence Analysis DNA General Medicine Infectious Diseases Carriage Vagina Female |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 31:233-235 |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/s10096-011-1298-7 |
| Popis: | During a national surveillance program on Group B streptococci (GBS) maternal carriage and neonatal infections, a GBS strain isolated from a pregnant woman's vagino-rectal swab was non typable by either serological or molecular methods. Further molecular characterization demonstrated that the strain lacked the entire capsular locus, possibly by a recombination event that excised a 14,1 Kbase pairs genomic fragment extending from the regulatory protein cpsX gene to the neuA gene. The natural loss of the capsular locus by GBS isolated from a human has never been described so far. Such an event, while possibly a dead-end from the evolutionary point of view, leaves a still able-to-colonize organism unrecognizable by the vaccines currently under development. |
| Databáze: | OpenAIRE |
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