Transfusion-associated adverse reactions (TAARs) and cytokine accumulations in the stored blood components: the impact of prestorage versus poststorage leukoreduction
| Autor: | Yi-Ting Chen, Fang-Yi Cheng, Fang-Yeh Chu, Hsiu-Chen Lin, Chih-Chun Chang, Tai-Chen Lee, Tzung-Hai Yen, Ming-Jang Su |
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| Rok vydání: | 2017 |
| Předmět: |
Allergy
business.industry medicine.medical_treatment febrile nonhemolytic transfusion reactions 030204 cardiovascular system & hematology transfusion-associated adverse reactions medicine.disease prestorage leukoreduction poststorage leukoreduction Tertiary care cytokines 03 medical and health sciences 0302 clinical medicine Cytokine Leukoreduction Apheresis Oncology Immunology medicine Blood units Platelet In patient business 030215 immunology Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Leukoreduction in blood units could prevent patients undergoing transfusions from transfusion-associated adverse reactions (TAARs) such as febrile nonhemolytic transfusion reactions (FNHTRs). However, the effect of prestorage and poststorage leukoreduction on TAARs and its underlying mechanisms in stored blood components remains to be determined. Therefore, we investigated the impact of prestorage leukocyte-reduced (pre-LR) and poststorage leukocyte-reduced (post-LR) blood products, including red blood cells (RBCs) and apheresis platelets (PHs), on the incidence of FNHTRs and other TAARs in patients who received transfusions from 2009 to 2014 in a tertiary care center. We also investigated the difference of leukocyte-related bioactive mediators between pre- and post-LR blood components. The results indicated that prevalence of TAARs was significantly reduced in the transfusions of pre-LR blood components. Particularly, the prevalence of FNHTRs was significantly reduced in the pre-LR RBC transfusions and the prevalence of allergy reactions was markedly reduced in the pre-LR PH transfusions. Furthermore, in vitro evaluation of cytokines in the pre- and post-LR blood components revealed that IL-1β, IL-8 and RANTES levels were significantly elevated in the post-LR RBCs during the storage. In contrast, IL-1β, IL-6 and IL-8 levels were significantly elevated in the post-LR PHs during the storage. These findings suggested that prestorage leukoreduction had a diminishing effect on the development of TAARs, which could be associated with less accumulation of cytokines in the stored blood components. |
| Databáze: | OpenAIRE |
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