The influence of propofol and midazolam/halothane anesthesia on hepatic SvO2 and gastric mucosal pH during cardiopulmonary bypass
| Autor: | Peter K. Paulsen, Christian L. Christiansen, Peter Ahlburg, Else Bay Andresen, Carl-Johan Jakobsen |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Midazolam Thermodilution Fentanyl law.invention Oxygen Consumption law Hypothermia Induced medicine Cardiopulmonary bypass Pressure Humans Pancuronium Prospective Studies Splanchnic Circulation Rewarming Propofol Aged Cardiopulmonary Bypass business.industry Hydrogen-Ion Concentration Middle Aged Cardiac surgery surgical procedures operative Anesthesiology and Pain Medicine medicine.anatomical_structure Liver Gastric Mucosa Anesthesia Anesthetic Anesthetics Inhalation Vascular resistance Vascular Resistance Halothane Cardiology and Cardiovascular Medicine business Anesthetics Intravenous medicine.drug Adjuvants Anesthesia Follow-Up Studies Liver Circulation Neuromuscular Nondepolarizing Agents |
| Zdroj: | Christiansen, C L, Ahlburg, P, Jakobsen, C-J, Andresen, E B & Paulsen, P K 1998, ' The influence of propofol and midazolam/halothane anesthesia on hepatic SvO2 and gastric mucosal pH during cardiopulmonary bypass ', Journal of Cardiothoracic and Vascular Anesthesia, vol. 12, no. 4, pp. 418-21 . |
| ISSN: | 1053-0770 |
| Popis: | Objective: Because propofol is known to reduce vascular resistance, the objective of this study was to compare the indices of hepatosplanchnic circulation and oxygenation during cardiopulmonary bypass (CPB) in patients anesthetized with either propofol or midazolam/halothane. Design: A prospective, randomized, nonblinded study. Setting: A university hospital. Participants: Twenty patients undergoing cardiac surgery with CPB. Interventions: Nine patients were anesthetized with propofol/fentanyl/pancuronium and 11 patients were anesthetized with midazolam/halothane/fentanyl/pancuronium. All patients had a nasogastric tonometer tube and two fiberoptic thermodilution catheters inserted; one in the pulmonary artery and one in the upper right hepatic vein. During bypass, SVO2s were measured from the venous line of the heart-lung machine. Measurements and Main Results: Gastric mucosal pH (pHi) was measured prebypass, 30 minutes after the start of CPB, and just before weaning off CPB. Hepatic SvO2 (HSvO2) values were recorded every 5 minutes. The pH gap was less at 30 minutes of hypothermic CPB in the propofol group. In the midazolam/halothane group, the HSvO2 decreased after the start of rewarming, whereas in the propofol group the values remained almost at the prebypass levels. At the end of rewarming, the HSvO2 was almost identical in the two groups. Conclusion: Propofol preserved the HSvO2 during CPB and produced a more optimal relationship between the hepatosplanchnic blood flow and oxygen consumption. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect