Immunocytochemical staining of pS2 protein in fine-needle aspirate from breast cancer is an accurate guide to response to tamoxifen in patients aged over 70 years
| Autor: | Nassif B.N. Ibrahim, C. J. H. Padfield, Y. G. Wilson, M. Rhodes, Simon Cawthorn |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Mammary gland Urology Breast Neoplasms Breast cancer medicine Carcinoma Humans Breast skin and connective tissue diseases Aged Chemotherapy Epithelioma business.industry Tumor Suppressor Proteins Biopsy Needle PS2 Protein Proteins Middle Aged medicine.disease Antiestrogen Immunohistochemistry Surgery Neoplasm Proteins Tamoxifen medicine.anatomical_structure Treatment Outcome Female Trefoil Factor-1 business medicine.drug |
| Zdroj: | The British journal of surgery. 81(8) |
| ISSN: | 0007-1323 |
| Popis: | Fine-needle aspirates from 52 breast cancers in 50 patients over 70 years of age were immunocytochemically stained for pS2 protein. All patients were treated with tamoxifen 40 mg/day and followed up at intervals of 2 months. The size of the tumour was serially assessed with calipers and portable ultrasonography. Change in tumour size was confirmed mammographically. Clinical monitoring was performed blind of the pS2 status. Twenty-five tumours were pS2 positive, of which 23 showed a significant response; ten went into complete remission (mean time to complete remission 6·8 (range 2–14) months) and 13 demonstrated partial remission (mean follow-up 8·9 (range 6–19) months). Two tumours remained static. Twenty-seven tumours were pS2 negative and none of these responded to tamoxifen; six remained static (mean follow-up 11·5 (range 6–14) months) and 21 progressed (mean time to progression 7·0 (range 3·14) months) (P < 0·001). Immunocytochemical assessment of fine-needle aspirates from elderly women with breast cancer accurately predicts a worthwhile response to tamoxifen. |
| Databáze: | OpenAIRE |
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