Autoimmune Cholangitis Presented as Fever of Unknown Origin
| Autor: | Iris Karachaliou, Konstantinos Papamichael, Kalypso Barbati, Antonios K. Zacharof, Georgios Karachalios, Constantinos L. Petrogiannopoulos, Nikolaos Kostakos |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Cholagogues and Choleretics
Cholangitis Anti-Inflammatory Agents medicine.disease_cause Fever of Unknown Origin Methylprednisolone Autoimmune Diseases Autoimmunity Immunopathology Drug Discovery Humans Medicine Pharmacology (medical) Fever of unknown origin Pharmacology Autoimmune disease biology medicine.diagnostic_test business.industry Ursodeoxycholic Acid gamma-Glutamyltransferase General Medicine Middle Aged Alkaline Phosphatase medicine.disease Ursodeoxycholic acid Infectious Diseases Oncology Liver biopsy Immunology biology.protein Female Antibody business Biomarkers medicine.drug |
| Zdroj: | Chemotherapy. 52:282-284 |
| ISSN: | 1421-9794 0009-3157 |
| DOI: | 10.1159/000095958 |
| Popis: | Autoimmune cholangitis is a rare chronic cholestatic liver disease. Fever of unknown origin is defined as a temperature higher than 38.3°C that lasts for more than 3 weeks with no obvious source despite appropriate investigation. We describe the case of a 62-year-old woman who presented with fever, fatigue and weight loss. The serum biochemical study showed an increase in alkaline phosphatase and γ-glutamyl transpeptidase levels. Antinuclear, antimitochondrial, anti-smooth-muscle antibodies and antibodies against the cytoplasm of neutrophils were negative. Liver biopsy was compatible with autoimmune cholangitis. The patient was successfully treated with methylprednisolone and ursodeoxycholic acid. We describe here a rare case of fever as preceding and leading symptom of autoimmune cholangitis. |
| Databáze: | OpenAIRE |
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