Targeting stemness of cancer stem cells to fight colorectal cancers
| Autor: | Lei Du, Lei Liu, Quan Chen, Hao Zheng, Jinming Liu, Qi Cheng |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
Cancer Research Colorectal cancer medicine.medical_treatment Tumor initiation Metastasis 03 medical and health sciences 0302 clinical medicine Cancer stem cell Cell Line Tumor medicine Humans business.industry Cancer Immunotherapy medicine.disease Cell Transformation Neoplastic 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell Neoplastic Stem Cells Cancer research Stem cell Colorectal Neoplasms business |
| Zdroj: | Seminars in Cancer Biology. 82:150-161 |
| ISSN: | 1044-579X |
| Popis: | Cancer initiating/ stem cells (CSCs) undergo self-renewal and differentiation that contributes to tumor initiation, recurrence and metastasis in colorectal cancer (CRC). Targeting of colorectal cancer stem cells (CCSCs) holds significant promise in eradicating cancer cells and ultimately curing patients with cancer. In this review, we will introduce the current progress of CCSC studies, including the specific surface markers of CCSCs, the intrinsic signaling pathways that regulate the stemness and differentiation characteristics of CCSCs, and the tumor organoid model for CCSC research. We will focus on how these studies will lead to the progress in targeting specific surface markers or signaling pathways on CCSCs by monoclonal antibodies, or by natural or synthetic compounds, or by immunotherapy. As CSCs are highly heterogeneous and plastic, we suggest that combinatory approaches that target the stemness network may represent an important strategy for eradicating cancers. |
| Databáze: | OpenAIRE |
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