Development of a Bioactive Fiber with Immobilized Synthetic Peptides Designed from the Active Site of a Beetle Defensin
| Autor: | Minoru Yamakawa, Makoto Nakamura, Takashi Iwasaki, Ai Asaoka, Jun Ishibashi, Seiji Tokino |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
chemistry.chemical_classification Polymers and Plastics biology Bioengineering Peptide biology.organism_classification medicine.disease_cause Coleoptera Biomaterials chemistry.chemical_compound Biochemistry chemistry Staphylococcus aureus Catalytic Domain Cancer cell Materials Chemistry medicine Animals Growth inhibition Peptides Cytotoxicity Defensin Bacteria Antibacterial agent |
| Zdroj: | Biomacromolecules. 12:1540-1545 |
| ISSN: | 1526-4602 1525-7797 |
| DOI: | 10.1021/bm1014969 |
| Popis: | The 9-mer peptides RLYLRIGRR and RLLLRIGRR were immobilized to amino-functionalized cotton fibers by a modification of the SPOT synthesis technique. The antibacterial activities of the peptide-immobilized cotton fibers against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) were investigated. Antibacterial assays revealed that these fibers inhibit the growth of MRSA and the antibacterial activities were maintained after washing and sterilization by autoclaving. The anticancer effect of the peptide-immobilized fiber was also investigated with mouse myeloma cells and human leukemia cells. These results indicate that these fibers have strong growth inhibition activity against bacteria and cancer cells. |
| Databáze: | OpenAIRE |
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