Effect of metformin on glycaemic control in type 2 diabetes in daily practice: a retrospective study
| Autor: | F. Holleman, Joost B. L. Hoekstra, A. M. E. Stades, J. T. Heikens |
|---|---|
| Přispěvatelé: | Other departments |
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Combination therapy medicine.medical_treatment Type 2 diabetes Internal medicine Diabetes Mellitus Internal Medicine Humans Hypoglycemic Agents Medicine Potency Obesity Retrospective Studies Glycated Hemoglobin Chemotherapy business.industry nutritional and metabolic diseases Retrospective cohort study Middle Aged medicine.disease Metformin Surgery Diabetes Mellitus Type 2 Case-Control Studies Metabolic control analysis Female medicine.symptom business Weight gain Follow-Up Studies medicine.drug |
| Zdroj: | Netherlands journal of medicine, 56(3), 86-90. Van Zuiden Communications BV |
| ISSN: | 0300-2977 |
| DOI: | 10.1016/s0300-2977(99)00128-x |
| Popis: | INTRODUCTION: Recently the UKPDS study revealed the potency of metformin therapy in obese type 2 diabetic patients. A retrospective study was performed to assess the efficacy of metformin therapy in improving metabolic control in everyday practice. PATIENTS AND METHODS: Type 2 diabetic patients were included if they met the following criteria: metformin had been added when the previous treatment failed to optimise glycaemic control expressed in HbA1c level; duration of metformin therapy had to be at least six months. Efficacy of metformin therapy, expressed as a decrease in HbA1c, was measured with a median follow-up of 32 (range 6-60) months. Variables were analysed using a paired t-test. RESULTS: One hundred and sixty-three patients were treated with metformin. 98 patients were excluded, because of absence of an HbA1c value prior to treatment with metformin mainly (n = 78). The mean HbA1c of included patients had decreased 1.4% (p |
| Databáze: | OpenAIRE |
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