Epidemiology and genetic diversity of zoonotic pathogens in urban rats (Rattus spp.) from a subtropical city, Guangzhou, southern China

Autor:	Qianqian Su, Qingxun Zhang, Yi Chen, Bo Wang, Shuyi Han, Chengmei Huang, Guohui Yuan, Hongxuan He
Rok vydání:	2020
Předmět:	0301 basic medicine Bartonella Male China Bartonella tribocorum Epidemiology animal diseases 030106 microbiology 030231 tropical medicine medicine.disease_cause Microbiology 03 medical and health sciences 0302 clinical medicine Hepatitis E virus Leptospira Zoonoses medicine Animals Cities Phylogeny Genetic diversity General Veterinary General Immunology and Microbiology biology Public Health Environmental and Occupational Health Genetic Variation bacterial infections and mycoses biology.organism_classification Bartonella rochalimae Bartonella elizabethae Rats Infectious Diseases bacteria Female Leptospira interrogans
Zdroj:	Zoonoses and public healthREFERENCES. 67(5)
ISSN:	1863-2378
Popis:	Commensal rats (Rattus spp.), which are globally distributed, harbour many pathogens responsible for significant human diseases. Despite this, we have a poor understanding of the epidemiology and genetic diversity of some recently neglected zoonotic pathogens, such as Leptospira spp., Bartonella spp. and hepatitis E virus (HEV), which constitute a major public health threat. Thus, we surveyed the occurrences, co-infection and genetic diversity of these pathogens in 129 urban rats from China. For Rattus tanezumi, the prevalences of Leptospira spp., Bartonella spp. and HEV infection were 6.67%, 0% and 46.67%, respectively. The prevalences of Leptospira spp., Bartonella spp. and HEV infection were 57.89%, 9.65% and 57.89% for Rattus norvegicus respectively. Leptospira spp. and HEV infections were more likely to occur in mature R. norvegicus. Phylogenetic analyses showed that pathogenic Leptospira interrogans and Leptospira borgpetersenii might exist. We also found that Bartonella spp. showed high similarity to Bartonella elizabethae, Bartonella rochalimae and Bartonella tribocorum, which are implicated in human disease. Dual and triple infections were both detected. Moreover, dual infections with Leptospira spp. and HEV represented the most frequent co-infection, and there was a significantly positive association between them. High genetic diversity was observed in genes segments from Leptospira, Bartonella and HEV. Our results first discover the occurrence of multiple co-infections and genetic diversity of Leptospira, Bartonella and HEV in commensal rats from China. Altogether, the present study provides an insight into evaluating the risk of rat-borne zoonoses in urban China.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadecb1198d60357cf38725d9ac6c9e4 https://pubmed.ncbi.nlm.nih.gov/32452163 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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