Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth

Autor: Ryoko Takasawa, Sei-ichi Tanuma, Yoko Ogino, Yusuke Takai, Risa Ichida, Minoru Morita, Takayuki Yamamoto, Sadao Mori, Hiroko Maruki-Uchida, Umehara Masahiro, Sai Masahiko, Atsushi Yoshimori, Aya Nishida, Mana Inada, Akira Sato, Nami Shimada
Rok vydání: 2019
Předmět:
0301 basic medicine
TCA
tricarboxylic acid
Biophysics
mTOR
mammalian target of rapamycin
PFSE
Passion fruit seed extract
Biochemistry
lcsh:Biochemistry
03 medical and health sciences
chemistry.chemical_compound
Lactoylglutathione lyase
0302 clinical medicine
lcsh:QD415-436
lcsh:QH301-705.5
Piceatannol
chemistry.chemical_classification
biology
Cancer cell proliferation
Methylglyoxal
Passion fruit seed extract
STAT3
signal transducers and activators of transcription 3
Glyoxalase I
IL-6
interleukin 6
Anticancer
030104 developmental biology
Enzyme
lcsh:Biology (General)
GLO I
glyoxalase I
chemistry
Cell culture
030220 oncology & carcinogenesis
MG
methylglyoxal
HPLC
high-performance liquid chromatography
Cancer cell
biology.protein
Passion fruit
PI3K
phosphoinositide 3-kinase
MAPK
mitogen-activated protein kinase
Research Article
Zdroj: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 20, Iss, Pp-(2019)
ISSN: 2405-5808
Popis: Passion fruit seed extract (PFSE), a product rich in stilbenes such as piceatannol and scirpusin B, has various physiological effects. It is unclear whether PFSE and its stilbene derivatives inhibit cancer cell proliferation via human glyoxalase I (GLO I), the rate-limiting enzyme for detoxification of methylglyoxal. We examined the anticancer effects of PFSE in two types of human cancer cell lines with different GLO I expression levels, NCI–H522 cells (highly-expressed GLO I) and HCT116 cells (lowly-expressed GLO I). PFSE and its stilbenes inhibited GLO I activity. In addition, PFSE and its stilbenes supressed the cancer cell proliferation of NCI–H522 cells more than HCT116 cells. These observations suggest that PFSE can provide a novel anticancer strategy for prevention and treatment.
Highlights • Piceatannol, and scirpusin B inhibited GLO I activity. • Passion fruit seed extract suppressed proliferation and colony formation of NCI–H522 cells. • Passion fruit seed extract and piceatannol could exert anticancer activity via GLO I inhibition.
Databáze: OpenAIRE
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