Effects of PF1022A on adultAngiostrongylus cantonensis in the pulmonary arteries and larvae migrating into the central nervous system of rats
| Autor: | Akira Ishih, Shigeo Kachi, Mamoru Terada |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Central Nervous System
Male medicine.medical_treatment Central nervous system Helminthiasis Administration Oral Physiology Pulmonary Artery Biology Peptides Cyclic Effective dose (radiation) Depsipeptides medicine Animals Anthelmintic Rats Wistar Feces Strongylida Infections Larva Chemotherapy General Veterinary Antinematodal Agents Angiostrongylus cantonensis General Medicine medicine.disease biology.organism_classification Rats Infectious Diseases medicine.anatomical_structure Insect Science Immunology Female Parasitology Injections Intraperitoneal medicine.drug |
| Zdroj: | Parasitology Research. 81:631-637 |
| ISSN: | 1432-1955 0044-3255 |
| DOI: | 10.1007/bf00931838 |
| Popis: | We examined the effects of PF1022A, newly developing in Japan, on adult Angiostrongylus cantonensis in the pulmonary arteries of rats. Following five and ten successive oral doses at 10 mg/kg per day, the first-stage larvae in rat faeces disappeared completely at 2 weeks after treatment. The treatment completely killed the female worms, but not the male worms. However, numbers of male worms were also decreased after the administration of either five successive oral doses at 10 mg/kg per day for four courses or five successive intraperitoneal doses at 0.5 mg/kg per day. Next, we examined the effects of PF1022A on larval A. cantonensis migrating into the central nervous system (CNS) of rats. Following five successive oral doses at 5 or 10 mg/kg per day and five successive intraperitoneal doses at 0.5 mg/kg per day, lesser killing effects were observed on male as well as female worms. On the basis of these results it is apparent that PF1022A will become a promising anthelmintic available as treatment for tissue-dwelling as well as intestinal nematodes. |
| Databáze: | OpenAIRE |
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