Pulmonary function impairment of asymptomatic and persistently symptomatic patients 4 months after COVID-19 according to disease severity
| Autor: | Tobias Veit, Carlo Mümmler, Johannes C. Hellmuth, Andreas Osterman, Alessandro Ghiani, Julien Dinkel, Elham Khatamzas, Maximilian Münchhoff, Pontus Mertsch, Michaela Barnikel, Julia Walter, Katrin Milger, Jürgen Barton, Nikolaus Kneidinger, Jürgen Behr, S Munker, Dieter Munker |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) medicine.medical_treatment Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pulmonary function impairment Disease Severity of Illness Index Asymptomatic Pulmonary function testing 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Internal medicine medicine Humans Prospective Studies 030212 general & internal medicine Respiratory system Lung Mechanical ventilation Original Paper SARS-CoV-2 business.industry COVID-19 Covid-19 Post-covid Pulmonary Function Impairment Sars-cov-2 General Medicine Infectious Diseases 030228 respiratory system Post-COVID medicine.symptom business |
| Zdroj: | Infection, DOI: 10.1007/s15010-021-01669-8 (2021) Infection |
| Popis: | Objective Evaluation of pulmonary function impairment after COVID-19 in persistently symptomatic and asymptomatic patients of all disease severities and characterisation of risk factors. Methods Patients with confirmed SARS-CoV-2 infection underwent prospective follow-up with pulmonary function testing and blood gas analysis during steady-state cycle exercise 4 months after acute illness. Pulmonary function impairment (PFI) was defined as reduction below 80% predicted of DLCOcSB, TLC, FVC, or FEV1. Clinical data were analyzed to identify risk factors for impaired pulmonary function. Results 76 patients were included, hereof 35 outpatients with mild disease and 41 patients hospitalized due to COVID-19. Sixteen patients had critical disease requiring mechanical ventilation, 25 patients had moderate–severe disease. After 4 months, 44 patients reported persisting respiratory symptoms. Significant PFI was prevalent in 40 patients (52.6%) occurring among all disease severities. The most common cause for PFI was reduced DLCOcSB (n = 39, 51.3%), followed by reduced TLC and FVC. The severity of PFI was significantly associated with mechanical ventilation (p p p = 0.014) and in hospitalized patients CT score. A decrease of paO2 > 3 mmHg during cycle exercise occurred in 1/5 of patients after mild disease course. Conclusion We characterized pulmonary function impairment in asymptomatic and persistently symptomatic patients of different severity groups of COVID-19 and identified further risk factors associated with persistently decreased pulmonary function. Remarkably, gas exchange abnormalities were revealed upon cycle exercise in some patients with mild disease courses and no preexisting pulmonary condition. |
| Databáze: | OpenAIRE |
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