Cocaethylene-induced kindling of seizure effects: cross-specificity with cocaine
| Autor: | Susanne M. Meehan, Martin D. Schechter |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Metabolite Clinical Biochemistry Convulsants Mice Inbred Strains Status epilepticus Neurological disorder Pharmacology Toxicology Biochemistry Behavioral Neuroscience chemistry.chemical_compound Mice Cocaethylene Status Epilepticus Cocaine Dopamine Uptake Inhibitors Seizures Convulsion medicine Kindling Neurologic Animals Drug Interactions Biological Psychiatry Sensitization Kindling medicine.disease medicine.anatomical_structure chemistry Toxicity Female Epilepsy Tonic-Clonic medicine.symptom Psychology medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 54(2) |
| ISSN: | 0091-3057 |
| Popis: | Sensitization and cross-sensitization to the seizurogenic effects of cocaine and cocaethylene were examined in the HS strain of mice. Animals were administered IP injections of either 48 mg/kg cocaine or 32 mg/kg cocaethylene once per day for 4 days. On the fifth day, mice were injected with either the same drug that was administered on days 1-4 or the alternative psychostimulant and the occurrence of seizure activity was recorded. Repeated cocaine administration resulted in the induction of tonic-clonic seizures and status epilepticus in 90% of the animals tested with cocaine on the fifth day. A similar increase in seizure prevalence, noted as a kindling effect, was observed in cocaethylene-treated animals tested with cocaethylene in that 90% of the mice exhibited status epilepticus on the last test day. Significant cross-sensitization was observed only in the group that received cocaethylene following repeated cocaine exposure. However, data obtained from animals injected with cocaine following cocaethylene treatment also were suggestive of cross-sensitization effects. Results are discussed in terms of the potential mechanistic differences between cocaine and its ethanol-derived product, as well as its relevance to cocaine use/abuse. |
| Databáze: | OpenAIRE |
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