Modified risk-stratified sequential treatment (subcutaneous rituximab with or without chemotherapy) in B-cell Post-transplant lymphoproliferative disorder (PTLD) after Solid organ transplantation (SOT): the prospective multicentre phase II PTLD-2 trial

Autor:	Heiner Zimmermann, Christian Koenecke, Martin H. Dreyling, Christiane Pott, Ulrich Dührsen, Dennis Hahn, Norbert Meidenbauer, Ingeborg A. Hauser, Mathias J. Rummel, Dominik Wolf, Michael Heuser, Christian Schmidt, Peter Schlattmann, Matthias Ritgen, Reiner Siebert, Ilske Oschlies, Ioannis Anagnostopoulos, Ralf U. Trappe
Rok vydání:	2022
Předmět:	Adult Cancer Research Oncology Antineoplastic Combined Chemotherapy Protocols Medizin Humans Organ Transplantation Prospective Studies Hematology Rituximab Lymphoproliferative Disorders
Zdroj:	Leukemia. 36:2468-2478
ISSN:	1476-5551 0887-6924
DOI:	10.1038/s41375-022-01667-1
Popis:	The prospective multicentre Phase II PTLD-2 trial (NCT02042391) tested modified risk-stratification in adult SOT recipients with CD20-positive PTLD based on principles established in the PTLD-1 trials: sequential treatment and risk-stratification. After rituximab monotherapy induction, patients in complete remission as well as those in partial remission with IPI p = 0.432). 2-year OS in the low-risk group was 100%. Results with R-CHOP-21 in high-risk patients confirmed previous results. Immunochemotherapy intensification in very-high-risk patients was disappointing.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadc4d3b2276cb6726230c29b16ae2e7 https://doi.org/10.1038/s41375-022-01667-1 Zobrazit plný text záznamu Full text from SpringerLink