| Autor: |
Brian P, Yaremko, Dante P I, Capaldi, Khadija, Sheikh, David A, Palma, Andrew, Warner, A Rashid, Dar, Edward, Yu, George B, Rodrigues, Alexander V, Louie, Mark, Landis, Michael, Sanatani, Mark D, Vincent, Jawaid, Younus, Sara, Kuruvilla, Jeff Z, Chen, Abigail, Erickson, Stewart, Gaede, Grace, Parraga, Douglas A, Hoover |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
International Journal of Radiation Oncology*Biology*Physics. 113:1072-1084 |
| ISSN: |
0360-3016 |
| DOI: |
10.1016/j.ijrobp.2022.04.047 |
| Popis: |
To determine whether functional lung avoidance based onPatients with stage III non-small cell lung cancer (or oligometastatic disease treated with curative intent) undergoing CCRT with at least a 10 pack-year smoking history were eligible. Patients underwent pretreatmentTwenty-seven patients were randomized before the trial was closed due to slower-than-expected accrual, with 11 randomized to the standard arm and 16 to the avoidance arm. Baseline patient characteristics were well-balanced. At 3 months post-RT, the mean ± SD LCS scores were 17.4 ± 2.8 versus 17.3 ± 6.1 for the standard and avoidance arms, respectively (P = .485). A clinically meaningful, prespecified decline of ≥3 points in the LCS score was observed in 50% (4/8) in the standard arm and 33% (4/12) in the avoidance arm (P = .648). Two patients in each arm developed grade ≥2 radiation pneumonitis, with no grade ≥4 toxicities.Although this trial did not reach full accrual, QOL scores were very similar between arms. Due to the scarcity of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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