Altered fecal microbial and metabolic profile reveals potential mechanisms underlying iron deficiency anemia in pregnant women in China
| Autor: | Haixia Chen, Weigang Wu, Shuming Tang, Rong Fu, Xia Gong, Hu Hou, Junfa Xu |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Bosnian Journal of Basic Medical Sciences. 22:923-933 |
| ISSN: | 1840-4812 1512-8601 |
| DOI: | 10.17305/bjbms.2022.7091 |
| Popis: | The gut microbiome and its metabolism may provide crucial insight into the cause of iron deficiency anemia (IDA) in pregnant women. This study aimed to investigate the effect of the gut microbiome and its related metabolites on pregnant women with iron deficiency (ID) and IDA. Maternal cubital venous blood and stool samples were collected from healthy control pregnant women (HC, non-anemic, n=10), pregnant women with ID non-anemia (ID, n=10), and IDA (n=10). All groups were subjected to fecal metagenomics and metabolomics. The composition and function of the gut microbiome were then compared in pregnant women with ID and IDA with HC after excluding the possibility of inflammation and insufficient iron absorption capacity. Whole-genome shotgun libraries were prepared by quantifying metagenomic DNA samples with Quant-iT PicoGreen dsDNA Assay. The levels of 41 microbial species, including 21 Streptococci and ten metabolites (catechol), which could serve as siderophores, were increased. In contrast, 3 Bacteroides and six metabolites were decreased in pregnant women with IDA (p |
| Databáze: | OpenAIRE |
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