Determination Of Chromatographic And Spectrophotometric Dissociation Constants Of Some Beta Lactam Antibiotics
| Autor: | Y. Doğan Daldal, Ebru Çubuk Demiralay, Cansel Cakır, Duygu Koç |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Activity coefficient
Chromatography Reverse-Phase Aqueous solution Chromatography Acetonitriles Chemistry Clinical Biochemistry Pharmaceutical Science Water Reversed-phase chromatography Mole fraction beta-Lactams Analytical Chemistry Anti-Bacterial Agents Dissociation constant Solubility Spectrophotometry Drug Discovery Nonlinear regression Spectroscopy Beta lactam antibiotics |
| Popis: | In this work, dissociation constants values of seven beta lactam antibiotics in water and acetonitrile-water mixtures using spectrophotometric and reversed phase liquid chromatography methods were determined. The dissociation constant values of these compounds were calculated by NLREG and STAR programs. Aqueous pK(a) values of beta lactam antibiotics were calculated with extrapolation by means of the Yasuda-Shedlovsky and mole fraction equations. Finally, application of the different techniques was compared to the determination of aqueous pK(a) values of investigated compounds. (C) 2012 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|