Colon Cancer Survival With Herbal Medicine and Vitamins Combined With Standard Therapy in a Whole-Systems Approach
| Autor: | Mark J. van der Laan, Michael Broffman, Michael McCulloch, Alan Hubbard, Lawrence H. Kushi, Jin Gao, John M. Colford, Donald I. Abrams |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Oncology medicine.medical_specialty Colorectal cancer Herbal Medicine medicine.medical_treatment Context (language use) Kaplan-Meier Estimate Traditional Chinese medicine Article Cohort Studies Internal medicine medicine Humans Combined Modality Therapy Prospective Studies Medicine Chinese Traditional Propensity Score Prospective cohort study Exercise Aged Neoplasm Staging Proportional Hazards Models Randomized Controlled Trials as Topic Proportional hazards model business.industry Cancer Vitamins Middle Aged medicine.disease Diet Surgery Radiation therapy Complementary and alternative medicine Colonic Neoplasms Female business Drugs Chinese Herbal Follow-Up Studies |
| Zdroj: | Integrative Cancer Therapies. 10:240-259 |
| ISSN: | 1552-695X 1534-7354 |
| DOI: | 10.1177/1534735411406539 |
| Popis: | Although localized colon cancer is often successfully treated with surgery, advanced disease requires aggressive systemic therapy that has lower effectiveness. Approximately 30% to 75% of patients with colon cancer use complementary and alternative medicine (CAM), but there is limited formal evidence of survival efficacy. In a consecutive case series with 10-year follow-up of all colon cancer patients (n = 193) presenting at a San Francisco Bay-Area center for Chinese medicine (Pine Street Clinic, San Anselmo, CA), the authors compared survival in patients choosing short-term treatment lasting the duration of chemotherapy/radiotherapy with those continuing long-term. To put these data into the context of treatment responses seen in conventional medical practice, they also compared survival with Pan-Asian medicine + vitamins (PAM+V) with that of concurrent external controls from Kaiser Permanente Northern California and California Cancer Registries. Kaplan-Meier, traditional Cox regression, and more modern methods were used for causal inference—namely, propensity score and marginal structural models (MSMs), which have not been used before in studies of cancer survival and Chinese herbal medicine. PAM+V combined with conventional therapy, compared with conventional therapy alone, reduced the risk of death in stage I by 95%, stage II by 64%, stage III by 29%, and stage IV by 75%. There was no significant difference between short-term and long-term PAM+V. Combining PAM+V with conventional therapy improved survival, compared with conventional therapy alone, suggesting that prospective trials combining PAM+V with conventional therapy are justified. |
| Databáze: | OpenAIRE |
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