Buspirone enhances head twitch behavior in mice
| Autor: | Tadashi Nagatani, Takami Watanabe, Yoshihisa Kitamura |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Agonist
Male medicine.medical_specialty medicine.drug_class Piperazines Buspirone 5-Hydroxytryptophan chemistry.chemical_compound Mice Internal medicine medicine Animals Drug Interactions Receptor 5-HT receptor Pharmacology Behavior Animal 8-OH-DPAT Body movement Pargyline Propranolol Endocrinology Mechanism of action chemistry Receptors Serotonin Serotonin Antagonists medicine.symptom medicine.drug |
| Zdroj: | European journal of pharmacology. 253(3) |
| ISSN: | 0014-2999 |
| Popis: | We studied the effects of buspirone, a 5-HT 1A receptor agonist, on head twitch behavior induced by 5-hydroxy- l -tryptophan (5-HTP) administered together with pargyline in mice. Buspirone dose dependently (0.1 − 10 mg/kg i.p.) enhanced head twitch behavior. This effect was blocked by (−)-propranolol and NAN-190 (1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]-piperazine hydrobromide). The enhancing effect of buspirone was also observed when mice were pretreated with p -chlorophenylalanine. These findings suggest that the enhancing effect of buspirone on head twitch behavior may be extended through the activation of post-synaptic 5-HT 1A receptors. |
| Databáze: | OpenAIRE |
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