Cognitive decline in Parkinson's disease : The impact of the motor phenotype on cognition
| Autor: | Katharina Linse, Hans-Ulrich Wittchen, Karsten Witt, Richard Dodel, Ines Ann Heber, Sandra Roeske, Ullrich Wüllner, Judith Dams, Claudia Trenkwalder, Nele Schmidt, Julia Heller, Rüdiger Hilker-Roggendorf, Oliver Riedel, Inga Liepelt-Scarfone, Sarah Rehberg, Monika Balzer-Geldsetzer, Petra Neuser, Daniela Berg, Jörg B. Schulz, Jennifer Wojtala, Günther Deuschl, Brit Mollenhauer, Susanne Gräber, Simon Baudrexel, Elke Kalbe, Annika Spottke, Alexander Storch, Carola Oberschmidt, Christine Schneider, Kathrin Reetz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty physiopathology [Cognitive Dysfunction] Trail Making Test Medizin Audiology Motor Activity Neuropsychological Tests Sensitivity and Specificity etiology [Cognitive Dysfunction] Cohort Studies 03 medical and health sciences Executive Function 0302 clinical medicine Germany medicine Dementia Humans Cognitive Dysfunction ddc:610 Cognitive decline Aged Aged 80 and over medicine.diagnostic_test business.industry Neuropsychology Wechsler Adult Intelligence Scale Cognition Parkinson Disease Neuropsychological test Middle Aged medicine.disease Executive functions physiology [Executive Function] Psychiatry and Mental health physiology [Motor Activity] Logistic Models Phenotype Surgery Female physiopathology [Parkinson Disease] Neurology (clinical) complications [Parkinson Disease] psychology [Parkinson Disease] business 030217 neurology & neurosurgery |
| Zdroj: | Journal of neurology, neurosurgery, and psychiatry 90(2), 171-179 (2019). doi:10.1136/jnnp-2018-319008 |
| Popis: | ObjectivesParkinson’s disease (PD) is the second most common neurodegenerative disorder and is further associated with progressive cognitive decline. In respect to motor phenotype, there is some evidence that akinetic-rigid PD is associated with a faster rate of cognitive decline in general and a greater risk of developing dementia.The objective of this study was to examine cognitive profiles among patients with PD by motor phenotypes and its relation to cognitive function.MethodsDemographic, clinical and neuropsychological cross-sectional baseline data of the DEMPARK/LANDSCAPE study, a multicentre longitudinal cohort study of 538 patients with PD were analysed, stratified by motor phenotype and cognitive syndrome. Analyses were performed for all patients and for each diagnostic group separately, controlling for age, gender, education and disease duration.ResultsCompared with the tremor-dominant phenotype, akinetic-rigid patients performed worse in executive functions such as working memory (Wechsler Memory Scale-Revised backward; p=0.012), formal-lexical word fluency (p=0.043), card sorting (p=0.006), attention (Trail Making Test version A; p=0.024) and visuospatial abilities (Leistungsprüfungssystem test 9; p=0.006). Akinetic-rigid neuropsychological test scores for the executive and attentive domain correlated negatively with non-tremor motor scores. Covariate-adjusted binary logistic regression analyses showed significant odds for PD-mild cognitive impairment for not-determined as compared with tremor-dominant (OR=3.198) and akinetic-rigid PD (OR=2.059). The odds for PD-dementia were significant for akinetic-rigid as compared with tremor-dominant phenotype (OR=8.314).ConclusionThe three motor phenotypes of PD differ in cognitive performance, showing that cognitive deficits seem to be less severe in tremor-dominant PD. While these data are cross-sectional, longitudinal data are needed to shed more light on these differential findings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|