Mature Dendritic Cells Infected with Herpes Simplex Virus Type 1 Exhibit Inhibited T-Cell Stimulatory Capacity
| Autor: | Monika Kruse, Joachim Hauber, Gerhard Stelz, Christine Kuhnt, Olaf Rosorius, Alexander Steinkasserer, Gerold Schuler, Friedrich Krätzer |
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| Rok vydání: | 2000 |
| Předmět: |
Transcription
Genetic T-Lymphocytes T cell Immunology Antigen presentation Immunoglobulins Herpesvirus 1 Human Lymphocyte Activation medicine.disease_cause Microbiology Herpesviridae Immune system Downregulation and upregulation Antigen Antigens CD Virology medicine Humans Cells Cultured Membrane Glycoproteins biology Virion Dendritic Cells Coculture Techniques Cell biology Phenotype medicine.anatomical_structure Herpes simplex virus Microscopy Fluorescence Insect Science biology.protein Pathogenesis and Immunity Antibody Lysosomes |
| Zdroj: | Journal of Virology. 74:7127-7136 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.74.15.7127-7136.2000 |
| Popis: | Mature dendritic cells (DC) are the most potent antigen-presenting cells within the entire immune system. Interference with the function of these cells therefore constitutes a very powerful mechanism for viruses to escape immune responses. Several members of theHerpesviridaefamily have provided examples of such escape strategies, including interference with antigen presentation and production of homologous cytokines. In this study we investigated the infection of mature DC with herpes simplex virus type 1 (HSV-1) and the way in which infection alters the phenotype and function of mature DC. Interestingly, the T-cell-stimulatory capacity of these DC was strongly impaired. Furthermore, we demonstrated that HSV-1 leads to the specific degradation of CD83, a cell surface molecule which is specifically upregulated during DC maturation. These data indicate that HSV-1 has developed yet another novel mechanism to escape immune responses. |
| Databáze: | OpenAIRE |
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