Elevated Hepcidin Is Part of a Complex Relation That Links Mortality with Iron Homeostasis and Anemia in Men and Women with HIV Infection
| Autor: | Hal Drakesmith, Andrew M. Prentice, Assan Jaye, Momodou W. Jallow, Joann M. McDermid, Bakary Darboe, Andrew E. Armitage, Peter A. Minchella |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Nutrition and Dietetics biology Anemia Medicine (miscellaneous) Transferrin receptor medicine.disease Ferritin Endocrinology chemistry Hepcidin Transferrin Internal medicine hemic and lymphatic diseases medicine biology.protein Erythropoiesis Hemoglobin Soluble transferrin receptor |
| ISSN: | 0022-3166 |
| Popis: | Background: Earlyandchronic inflammation isahallmarkof HIVinfection, and inflammationisknown toincrease hepcidinexpression. Consequently, hepcidin may be a key determinant of the iron homeostasis and anemia associated with poorer HIV prognoses. Objective: The objective of this study was to understand how hepcidin is related to anemia, iron homeostasis, and inflammation at HIV diagnosis and to investigate associations between hepcidin and all-cause mortality in HIV infection. Methods: In a retrospective cohort, baseline plasma hepcidin was measured by competitive enzyme immunoassay within 3 mo of HIV diagnosis in 196 antiretroviral-naive Gambians. Iron homeostasis [hemoglobin, plasma transferrin, ferritin, iron, soluble transferrin receptor (sTfR)] and inflammation [a1-antichymotrypsin (ACT)] from the same plasma sample were available, as were absolute CD4 cell counts, age, gender, body mass index (BMI), and HIV type. Results: Anemia was common across the spectrum of immunosuppression [CD4 cell counts (prevalence of anemia): >500 cells/mL (68%), 200‐500 cells/mL (73%), and |
| Databáze: | OpenAIRE |
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