Thymic Extranodal Marginal Zone Lymphoma of Mucosa-associated Lymphoid Tissue with 8q24 Abnormality
| Autor: | Koichi Ohshima, Koichi Nagai, Takeshi Sakai, Sadao Aoki, Akihito Momoi, Noriatsu Isahai |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Genes myc Chromosomal translocation Pathogenesis 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases Internal Medicine medicine Humans B cell Chromosome Aberrations business.industry MALT lymphoma Lymphoma B-Cell Marginal Zone Thymus Neoplasms General Medicine Middle Aged medicine.disease BCL10 Lymphoma Sjogren's Syndrome 030104 developmental biology medicine.anatomical_structure Lymphatic system 030220 oncology & carcinogenesis Female business Mucosa-associated lymphoid tissue |
| Zdroj: | Internal Medicine. 55:799-803 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.55.5693 |
| Popis: | Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the thymus is reported to have characteristic features that distinguish it from MALT lymphoma of other organs; it is proposed to be a distinct clinicopathological subgroup of MALT lymphoma. We herein present a case of thymic MALT lymphoma accompanied by Sjögren's syndrome, involving the first report of a thymic MALT lymphoma patient carrying a chromosomal abnormality of 8q24. No c-myc gene translocation or c-Myc protein overexpression was observed, suggesting that c-myc was not involved in lymphomagenesis or progression. Although we did not examine the mechanisms by which the lymphoma developed, this chromosomal structural change in 8q24 may be associated with the pathogenesis in our case. |
| Databáze: | OpenAIRE |
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