Unpredictable chronic mild stress differentially impairs social and contextual discrimination learning in two inbred mouse strains

Autor: Zsuzsanna Callaerts-Vegh, Patrick Callaerts, Michiel Van Boxelaere, Jason Clements, Rudi D'Hooge
Přispěvatelé: Neurology
Rok vydání: 2017
Předmět:
RNA
Messenger/genetics
0301 basic medicine
Social Sciences
lcsh:Medicine
Hippocampus
Conditioning (Psychology)
Discrimination Learning
Mice
Corticosterone/blood
0302 clinical medicine
Sociology
Conditioning
Psychological
Medicine and Health Sciences
Tyrosine 3-Monooxygenase/genetics
Psychology
Medicine
Chronic stress
lcsh:Science
Prefrontal cortex
Mammals
Cognitive Impairment
Medicine(all)
Multidisciplinary
Animal Behavior
Behavior
Animal
Cognitive Neurology
Post-Traumatic Stress Disorder
Eukaryota
Brain
Cognition
Social Discrimination
anxiety
Anxiety Disorders
Neurology
Mice
Inbred DBA
Stress
Psychological/genetics
Vertebrates
Anxiety
Female
Anatomy
medicine.symptom
Research Article
medicine.medical_specialty
Tyrosine 3-Monooxygenase
Cognitive Neuroscience
Hippocampus/metabolism
Prefrontal Cortex
Psychological Stress
Neuropsychiatric Disorders
Neuroses
Rodents
social behavior
body weight
03 medical and health sciences
Social cognition
Mental Health and Psychiatry
Neuroplasticity
Animals
RNA
Messenger
Psychiatry
Brain-derived neurotrophic factor
Behavior
business.industry
lcsh:R
Organisms
Biology and Life Sciences
Mice
Inbred C57BL
030104 developmental biology
Gene Expression Regulation
Amniotes
Exploratory Behavior
Cognitive Science
lcsh:Q
Corticosterone
business
Zoology
chronic disease
Neuroscience
Biomarkers
Stress
Psychological
Biomarkers/blood
030217 neurology & neurosurgery
Zdroj: PLoS ONE, Vol 12, Iss 11, p e0188537 (2017)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0188537
Popis: Alterations in the social and cognitive domain are considered important indicators for increased disability in many stress-related disorders. Similar impairments have been observed in rodents chronically exposed to stress, mimicking potential endophenotypes of stress-related psychopathologies such as major depression disorder (MDD), anxiety, conduct disorder, and posttraumatic stress disorder (PTSD). Data from numerous studies suggest that deficient plasticity mechanisms in hippocampus (HC) and prefrontal cortex (PFC) might underlie these social and cognitive deficits. Specifically, stress-induced deficiencies in neural plasticity have been associated with a hypodopaminergic state and reduced neural plasticity persistence. Here we assessed the effects of unpredictable chronic mild stress (UCMS) on exploratory, social and cognitive behavior of females of two inbred mouse strains (C57BL/6J and DBA/2J) that differ in their dopaminergic profile. Exposure to chronic stress resulted in impaired circadian rhythmicity, sociability and social cognition in both inbred strains, but differentially affected activity patterns and contextual discrimination performance. These stress-induced behavioral impairments were accompanied by reduced expression levels of brain derived neurotrophic factor (BDNF) in the prefrontal cortex. The strain-specific cognitive impairment was coexistent with enhanced plasma corticosterone levels and reduced expression of genes related to dopamine signaling in hippocampus. These results underline the importance of assessing different strains with multiple test batteries to elucidate the neural and genetic basis of social and cognitive impairments related to chronic stress. ispartof: PLoS One vol:12 issue:11 ispartof: location:United States status: published
Databáze: OpenAIRE
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