Estimating the burden of iron deficiency among African children
| Autor: | Thomas N. Williams, Wandia Kimita, Francis M. Ndungu, Alexander J. Mentzer, Parminder S. Suchdev, Alfred B. Tiono, Sarah H. Atkinson, Swaib A. Lule, Rosie J. Crane, Sodiomon B. Sirima, Adrian V. S. Hill, Alison M. Elliott, Shabir A. Madhi, Philip Bejon, James A. Berkley, Andrew M. Prentice, Alireza Morovat, Emily L. Webb, Alex Macharia, Amidou Diarra, Clare L. Cutland, John Muthii Muriuki |
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| Přispěvatelé: | Wellcome Trust |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty lcsh:Medicine Parasitemia Transferrin saturation 03 medical and health sciences 0302 clinical medicine General & Internal Medicine Internal medicine parasitic diseases Humans Medicine 030212 general & internal medicine Child 11 Medical and Health Sciences 2. Zero hunger Inflammation Ferritin Anemia Iron-Deficiency biology business.industry Public health Iron deficiency lcsh:R Infant Newborn Infant General Medicine Guideline Gold standard (test) medicine.disease 3. Good health Malaria 030104 developmental biology Child Preschool Africa biology.protein Female African children business Research Article |
| Zdroj: | BMC Medicine, Vol 18, Iss 1, Pp 1-14 (2020) BMC Medicine |
| ISSN: | 1741-7015 |
| Popis: | Background Iron deficiency (ID) is a major public health burden in African children and accurate prevalence estimates are important for effective nutritional interventions. However, ID may be incorrectly estimated in Africa because most measures of iron status are altered by inflammation and infections such as malaria. Through the current study, we have assessed different approaches to the prediction of iron status and estimated the burden of ID in African children. Methods We assayed iron and inflammatory biomarkers in 4853 children aged 0–8 years from Kenya, Uganda, Burkina Faso, South Africa, and The Gambia. We described iron status and its relationship with age, sex, inflammation, and malaria parasitemia. We defined ID using the WHO guideline (ferritin Results The prevalence of ID was highest at 1 year of age and in male infants. Inflammation and malaria parasitemia were associated with all iron biomarkers, although transferrin saturation was least affected. Overall prevalence of WHO-defined ID was 34% compared to 52% using the inflammation and malaria regression-corrected estimate. This unidentified burden of ID increased with age and was highest in countries with high prevalence of inflammation and malaria, where up to a quarter of iron-deficient children were misclassified as iron replete. Transferrin saturation Conclusions The prevalence of ID is underestimated in African children when defined using the WHO guidelines, especially in malaria-endemic populations, and the use of transferrin saturation may provide a more accurate approach. Further research is needed to identify the most accurate measures for determining the prevalence of ID in sub-Saharan Africa. |
| Databáze: | OpenAIRE |
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